"CD4 Antigens" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
55-kDa antigens found on HELPER-INDUCER T-LYMPHOCYTES and on a variety of other immune cell types. They are members of the immunoglobulin supergene family and are implicated as associative recognition elements in MAJOR HISTOCOMPATIBILITY COMPLEX class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. T4 antigens also serve as INTERLEUKIN-15 receptors and bind to the HIV receptors, binding directly to the HIV ENVELOPE PROTEIN GP120.
| Descriptor ID |
D015704
|
| MeSH Number(s) |
D12.776.543.750.705.852.420.810.500 D12.776.543.750.830.700.025 D23.050.301.264.894.100 D23.101.100.894.100
|
| Concept/Terms |
CD4 Antigens- CD4 Antigens
- Antigens, CD4
- CD4 Molecule
- T4 Antigens, T-Cell
- Antigens, T-Cell T4
- T-Cell T4 Antigens
- T4 Antigens, T Cell
- Receptors, CD4
- Surface CD4 Receptor
- CD4 Receptor, Surface
- Receptors, Surface CD4
- CD4 Receptors, Surface
- Surface CD4 Receptors
- CD4 Antigen
- Antigen, CD4
- CD4 Receptors
|
Below are MeSH descriptors whose meaning is more general than "CD4 Antigens".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Membrane Proteins [D12.776.543]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, Immunologic [D12.776.543.750.705]
- Receptors, Cytokine [D12.776.543.750.705.852]
- Receptors, Interleukin [D12.776.543.750.705.852.420]
- Receptors, Interleukin-16 [D12.776.543.750.705.852.420.810]
- CD4 Antigens [D12.776.543.750.705.852.420.810.500]
- Receptors, Virus [D12.776.543.750.830]
- Receptors, HIV [D12.776.543.750.830.700]
- CD4 Antigens [D12.776.543.750.830.700.025]
- Biological Factors [D23]
- Antigens [D23.050]
- Antigens, Surface [D23.050.301]
- Antigens, Differentiation [D23.050.301.264]
- Antigens, Differentiation, T-Lymphocyte [D23.050.301.264.894]
- CD4 Antigens [D23.050.301.264.894.100]
- Biomarkers [D23.101]
- Antigens, Differentiation [D23.101.100]
- Antigens, Differentiation, T-Lymphocyte [D23.101.100.894]
- CD4 Antigens [D23.101.100.894.100]
Below are MeSH descriptors whose meaning is more specific than "CD4 Antigens".
This graph shows the total number of publications written about "CD4 Antigens" by people in this website by year, and whether "CD4 Antigens" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2008 | 0 | 2 | 2 |
| 2010 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 2 | 1 | 3 |
| 2013 | 0 | 2 | 2 |
| 2014 | 2 | 1 | 3 |
| 2015 | 1 | 0 | 1 |
| 2016 | 3 | 1 | 4 |
| 2017 | 0 | 1 | 1 |
| 2018 | 1 | 3 | 4 |
| 2019 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "CD4 Antigens" by people in Profiles.
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Covalent binding of human two-domain CD4 to an HIV-1 subtype C SOSIP.664 trimer modulates its structural dynamics. Biochem Biophys Res Commun. 2022 07 05; 612:181-187.
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Rapid and Focused Maturation of a VRC01-Class HIV Broadly Neutralizing Antibody Lineage Involves Both Binding and Accommodation of the N276-Glycan. Immunity. 2019 07 16; 51(1):141-154.e6.
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Structural Rearrangements Maintain the Glycan Shield of an HIV-1 Envelope Trimer After the Loss of a Glycan. Sci Rep. 2018 10 09; 8(1):15031.
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Medroxyprogesterone acetate, unlike norethisterone, increases HIV-1 replication in human peripheral blood mononuclear cells and an indicator cell line, via mechanisms involving the glucocorticoid receptor, increased CD4/CD8 ratios and CCR5 levels. PLoS One. 2018; 13(4):e0196043.
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Relevance and acceptability of using the Quantiferon gold test (QGIT) to screen CD4 blood draws for latent TB infection among PLHIV in South Africa: formative qualitative research findings from the TEKO trial. BMC Health Serv Res. 2018 04 16; 18(1):288.
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Redox exchange of the disulfides of human two-domain CD4 regulates the conformational dynamics of each domain, providing insight into its mechanisms of control. Biochem Biophys Res Commun. 2018 03 04; 497(2):811-817.
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Structure and Recognition of a Novel HIV-1 gp120-gp41 Interface Antibody that Caused MPER Exposure through Viral Escape. PLoS Pathog. 2017 01; 13(1):e1006074.
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Structure of an N276-Dependent HIV-1 Neutralizing Antibody Targeting a Rare V5 Glycan Hole Adjacent to the CD4 Binding Site. J Virol. 2016 Nov 15; 90(22):10220-10235.
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Thioredoxin (Trx1) regulates CD4 membrane domain localization and is required for efficient CD4-dependent HIV-1 entry. Biochim Biophys Acta. 2016 09; 1860(9):1854-63.
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Human CD4 Metastability Is a Function of the Allosteric Disulfide Bond in Domain 2. Biochemistry. 2016 Apr 19; 55(15):2227-37.