"CD3 Complex" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA).
Descriptor ID |
D017252
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MeSH Number(s) |
D23.050.301.264.894.095 D23.101.100.894.095
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Concept/Terms |
CD3 Complex- CD3 Complex
- T3 Antigens
- Antigens, T3
- T3 Complex
- CD3 Antigens
- Antigens, CD3
- T3 Antigen
- Antigen, T3
- CD3 Antigen
- Antigen, CD3
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Below are MeSH descriptors whose meaning is more general than "CD3 Complex".
Below are MeSH descriptors whose meaning is more specific than "CD3 Complex".
This graph shows the total number of publications written about "CD3 Complex" by people in this website by year, and whether "CD3 Complex" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1998 | 0 | 1 | 1 |
2001 | 0 | 1 | 1 |
2003 | 0 | 1 | 1 |
2008 | 0 | 1 | 1 |
2009 | 0 | 1 | 1 |
2010 | 0 | 1 | 1 |
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Below are the most recent publications written about "CD3 Complex" by people in Profiles.
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FOXP3 expression is upregulated in CD4T cells in progressive HIV-1 infection and is a marker of disease severity. PLoS One. 2010 Jul 23; 5(7):e11762.
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Cutting Edge: Unusual NK cell responses to HIV-1 peptides are associated with protection against maternal-infant transmission of HIV-1. J Immunol. 2009 May 15; 182(10):5914-8.
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Large-scale affordable PanLeucogated CD4+ testing with proactive internal and external quality assessment: in support of the South African national comprehensive care, treatment and management programme for HIV and AIDS. Cytometry B Clin Cytom. 2008; 74 Suppl 1:S40-51.
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Comparison of intracellular cytokine production with extracellular cytokine levels using two flow cytometric techniques. Cytometry B Clin Cytom. 2003 Sep; 55(1):52-8.
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Expression of inhibitory receptors in natural killer (CD3(-)CD56(+)) cells and CD3(+)CD56(+) cells in the peripheral blood lymphocytes and tumor infiltrating lymphocytes in patients with primary hepatocellular carcinoma. Clin Immunol. 2001 Dec; 101(3):264-9.
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Interleukin-18 (IFNgamma-inducing factor) induces IL-8 and IL-1beta via TNFalpha production from non-CD14+ human blood mononuclear cells. J Clin Invest. 1998 Feb 01; 101(3):711-21.