Protein Structure, Tertiary
"Protein Structure, Tertiary" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The level of protein structure in which combinations of secondary protein structures (ALPHA HELICES; BETA SHEETS; loop regions, and AMINO ACID MOTIFS) pack together to form folded shapes. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure.
Descriptor ID |
D017434
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MeSH Number(s) |
G02.111.570.820.709.610
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Concept/Terms |
Protein Structure, Tertiary- Protein Structure, Tertiary
- Tertiary Protein Structure
- Protein Structures, Tertiary
- Tertiary Protein Structures
|
Below are MeSH descriptors whose meaning is more general than "Protein Structure, Tertiary".
Below are MeSH descriptors whose meaning is more specific than "Protein Structure, Tertiary".
This graph shows the total number of publications written about "Protein Structure, Tertiary" by people in this website by year, and whether "Protein Structure, Tertiary" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1996 | 0 | 1 | 1 |
2001 | 0 | 1 | 1 |
2004 | 0 | 1 | 1 |
2008 | 0 | 1 | 1 |
2009 | 0 | 2 | 2 |
2011 | 0 | 1 | 1 |
2014 | 0 | 4 | 4 |
2015 | 0 | 2 | 2 |
2016 | 0 | 2 | 2 |
2018 | 0 | 1 | 1 |
2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Protein Structure, Tertiary" by people in Profiles.
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Interaction of the spike protein RBD from SARS-CoV-2 with ACE2: Similarity with SARS-CoV, hot-spot analysis and effect of the receptor polymorphism. Biochem Biophys Res Commun. 2020 06 30; 527(3):702-708.
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Redox exchange of the disulfides of human two-domain CD4 regulates the conformational dynamics of each domain, providing insight into its mechanisms of control. Biochem Biophys Res Commun. 2018 03 04; 497(2):811-817.
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New antiprotozoal agents: Synthesis and biological evaluation of different 4-(7-chloroquinolin-4-yl) piperazin-1-yl)pyrrolidin-2-yl)methanone derivatives. Bioorg Med Chem Lett. 2017 02 01; 27(3):460-465.
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Human CD4 Metastability Is a Function of the Allosteric Disulfide Bond in Domain 2. Biochemistry. 2016 Apr 19; 55(15):2227-37.
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Changes in the amino acid sequence of the recombinant human factor VIIa analog, vatreptacog alfa, are associated with clinical immunogenicity. J Thromb Haemost. 2015 Nov; 13(11):1989-98.
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Functional roles of HIV-1 Vpu and CD74: Details and implications of the Vpu-CD74 interaction. Cell Immunol. 2015 Nov-Dec; 298(1-2):25-32.
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A fusion intermediate gp41 immunogen elicits neutralizing antibodies to HIV-1. J Biol Chem. 2014 Oct 24; 289(43):29912-26.
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Lower frequency of NPM1 and FLT3-ITD mutations in a South African adult de novo AML cohort. Int J Lab Hematol. 2014 Dec; 36(6):656-64.
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Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies. Nature. 2014 May 01; 509(7498):55-62.
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Disulfide reduction in CD4 domain 1 or 2 is essential for interaction with HIV glycoprotein 120 (gp120), which impairs thioredoxin-driven CD4 dimerization. J Biol Chem. 2014 Apr 11; 289(15):10455-10465.