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Houcemeddine

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ben Haj Othmen H, Othman H, Khamessi O, Bettaieb I, Gara S, Kharrat M. Overexpression of WT1 in all molecular subtypes of breast cancer and its impact on survival: exploring oncogenic and tumor suppressor roles of distinct WT1 isoforms. Mol Biol Rep. 2024 Apr 20; 51(1):544. PMID: 38642153.
      Citations:    Fields:    Translation:Humans
    2. Ndong Sima CAA, Othman H, M?ller M, Project Africa GRADIENT Consortium. Advancing pharmacogenetics research in Africa: the "Project Africa GRADIENT" initiative. Drug Discov Today. 2024 May; 29(5):103939. PMID: 38430965.
      Citations:    Fields:    Translation:Humans
    3. Ghedira K, Khamessi O, Hkimi C, Kamoun S, Dhamer N, Daassi K, Ben Salah W, Othman H, Belhadj W, Ghorbal Y. Design and implementation of a scalable high-performance computing (HPC) cluster for omics data analysis: achievements, challenges and recommendations in LMICs. Gigascience. 2024 Jan 02; 13. PMID: 39172543; PMCID: PMC11340639.
      Citations:    Fields:    Translation:Humans
    4. Ghedira K, Dallali H, Ardhaoui M, Bouslema Z, Hamdi Y, Feki Ben-Salah S, Chelbi H, Atri C, Chaouch M, Dekhil N, Rais A, Azouz S, Gharbi M, Guerfali F, Hkimi C, Kamoun S, Ksouri A, Moumni I, Ouragini H, Bsibes R, Afifi Z, Youssfi K, Ben Hassine H, Hadhri N, Mardassi H, Othman H, Khamessi O. PHINDaccess Hackathons for COVID-19 and Host-Pathogen Interaction: Lessons Learned and Recommendations for Low- and Middle-Income Countries. Biomed Res Int. 2023; 2023:6638714. PMID: 37854792; PMCID: PMC10581832.
      Citations: 1     Fields:    Translation:HumansCellsPHPublic Health
    5. Khoza N, Twesigomwe D, Othman H. Characterizing the combined effects of cytochrome P450 missense variation within star allele definitions. Pharmacogenomics. 2023 07; 24(10):561-578. PMID: 37503750.
      Citations:    Fields:    Translation:Humans
    6. Sitabule BR, Othman H, Choudhury A, Twesigomwe D, Hanchard NA. Promoting Pharmacogenomics in Africa: Perspectives From Variation in G6PD and Other Pharmacogenes. Clin Pharmacol Ther. 2023 03; 113(3):476-479. PMID: 36576133.
      Citations: 2     Fields:    Translation:Humans
    7. Ksibi B, Ktari S, Ghedira K, Othman H, Maalej S, Mnif B, Fabre L, Rhimi F, Hello SL, Hammami A. Antimicrobial resistance genes, virulence markers and prophage sequences in Salmonella enterica serovar Enteritidis isolated in Tunisia using whole genome sequencing. Curr Res Microb Sci. 2022; 3:100151. PMID: 35909609; PMCID: PMC9325895.
      Citations: 1     
    8. Batista da Rocha J, Othman H, Hazelhurst S. Molecular dynamics of G6PD variants from sub-Saharan Africa. Biochem Biophys Rep. 2022 Jul; 30:101236. PMID: 35313643; PMCID: PMC8933681.
      Citations:    
    9. Othman H, Messaoud HB, Khamessi O, Ben-Mabrouk H, Ghedira K, Bharuthram A, Treurnicht F, Achilonu I, Sayed Y, Srairi-Abid N. SARS-CoV-2 Spike Protein Unlikely to Bind to Integrins via the Arg-Gly-Asp (RGD) Motif of the Receptor Binding Domain: Evidence From Structural Analysis and Microscale Accelerated Molecular Dynamics. Front Mol Biosci. 2022; 9:834857. PMID: 35237662; PMCID: PMC8883519.
      Citations: 8     
    10. Othman H, Jemimah S, da Rocha JEB. SWAAT Bioinformatics Workflow for Protein Structure-Based Annotation of ADME Gene Variants. J Pers Med. 2022 Feb 11; 12(2). PMID: 35207751; PMCID: PMC8875676.
      Citations: 1     
    11. Othman H, Zass L, da Rocha JEB, Radouani F, Samtal C, Benamri I, Kumuthini J, Fakim YJ, Hamdi Y, Mezzi N, Boujemaa M, Okeke CJ, Tendwa MB, Sanak K, Chaouch M, Panji S, Kefi R, Sallam RM, Ghoorah AW, Romdhane L, Kiran A, Meintjes AP, Maturure P, Jmel H, Ksouri A, Azzouzi M, Farahat MA, Ahmed S, Sibira R, Turkson MEE, Ssekagiri A, Parker Z, Fadlelmola FM, Ghedira K, Mulder N, Kamal Kassim S. African Genomic Medicine Portal: A Web Portal for Biomedical Applications. J Pers Med. 2022 Feb 11; 12(2). PMID: 35207753; PMCID: PMC8879570.
      Citations:    
    12. Aissaoui-Zid D, Saada MC, Moslah W, Potier-Cartereau M, Lemettre A, Othman H, Gaysinski M, Abdelkafi-Koubaa Z, Souid S, Marrakchi N, Vandier C, Essafi-Benkhadir K, Srairi-Abid N. AaTs-1: A Tetrapeptide from Androctonus australis Scorpion Venom, Inhibiting U87 Glioblastoma Cells Proliferation by p53 and FPRL-1 Up-Regulations. Molecules. 2021 Dec 15; 26(24). PMID: 34946686; PMCID: PMC8704564.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    13. da Rocha JEB, Othman H, Tiemessen CT, Botha G, Ramsay M, Masimirembwa C, Adebamowo C, Choudhury A, Brandenburg JT, Matshaba M, Simo G, Gamo FJ, Hazelhurst S, as members of the H3Africa Consortium. G6PD distribution in sub-Saharan Africa and potential risks of using chloroquine/hydroxychloroquine based treatments for COVID-19. Pharmacogenomics J. 2021 12; 21(6):649-656. PMID: 34302047; PMCID: PMC8299738.
      Citations: 8     Fields:    Translation:Humans
    14. Othman H, da Rocha JEB, Hazelhurst S. Single Nucleotide Polymorphism Induces Divergent Dynamic Patterns in CYP3A5: A Microsecond Scale Biomolecular Simulation of Variants Identified in Sub-Saharan African Populations. Int J Mol Sci. 2021 Jul 21; 22(15). PMID: 34360551; PMCID: PMC8346100.
      Citations: 1     Fields:    Translation:Humans
    15. Mulder N, Zass L, Hamdi Y, Othman H, Panji S, Allali I, Fakim YJ. African Global Representation in Biomedical Sciences. Annu Rev Biomed Data Sci. 2021 07 20; 4:57-81. PMID: 34465182.
      Citations: 5     Fields:    Translation:Humans
    16. da Rocha JEB, Othman H, Botha G, Cottino L, Twesigomwe D, Ahmed S, Drögemöller BI, Fadlelmola FM, Machanick P, Mbiyavanga M, Panji S, Wright GEB, Adebamowo C, Matshaba M, Ramsay M, Simo G, Simuunza MC, Tiemessen CT, Baldwin S, Chiano M, Cox C, Gross AS, Thomas P, Gamo FJ, Hazelhurst S. The Extent and Impact of Variation in ADME Genes in Sub-Saharan African Populations. Front Pharmacol. 2021; 12:634016. PMID: 34721006; PMCID: PMC8549571.
      Citations: 14     
    17. Haddad-Boubaker S, Othman H, Touati R, Ayouni K, Lakhal M, Ben Mustapha I, Ghedira K, Kharrat M, Triki H. In silico comparative study of SARS-CoV-2 proteins and antigenic proteins in BCG, OPV, MMR and other vaccines: evidence of a possible putative protective effect. BMC Bioinformatics. 2021 Mar 26; 22(1):163. PMID: 33771096; PMCID: PMC7995392.
      Citations: 17     Fields:    Translation:HumansCells
    18. Ghedira K, Hamdi Y, El Béji A, Othman H. An Integrative Computational Approach for the Prediction of Human-Plasmodium Protein-Protein Interactions. Biomed Res Int. 2020; 2020:2082540. PMID: 33426052; PMCID: PMC7771252.
      Citations: 2     Fields:    Translation:HumansAnimals
    19. Ghedira K, Kouidhi S, Hamdi Y, Othman H, Kechaou S, Znaidi S, Haïtham S, Rabhi I. Pathway Maps of Orphan and Complex Diseases Using an Integrative Computational Approach. Biomed Res Int. 2020; 2020:4280467. PMID: 33376724; PMCID: PMC7744584.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    20. Mighri N, Hamdi Y, Boujemaa M, Othman H, Ben Nasr S, El Benna H, Mejri N, Labidi S, Ayari J, Jaidene O, Bouaziz H, Ben Rekaya M, M'rad R, Haddaoui A, Rahal K, Boussen H, Boubaker S, Abdelhak S. Identification of Novel BRCA1 and RAD50 Mutations Associated With Breast Cancer Predisposition in Tunisian Patients. Front Genet. 2020; 11:552971. PMID: 33240314; PMCID: PMC7677579.
      Citations: 7     
    21. Ksibi B, Ktari S, Othman H, Ghedira K, Maalej S, Mnif B, Abbassi MS, Fabre L, Rhimi F, Le Hello S, Hammami A. Comparison of conventional molecular and whole-genome sequencing methods for subtyping Salmonella enterica serovar Enteritidis strains from Tunisia. Eur J Clin Microbiol Infect Dis. 2021 Mar; 40(3):597-606. PMID: 33030625.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    22. da Rocha J, Othman H, Tiemessen CT, Botha G, Ramsay M, Masimirembwa C, Adebamowo C, Choudhury A, Brandenburg JT, Matshaba M, Simo G, Gamo FJ, Hazelhurst S. G6PD variant distribution in sub-Saharan Africa and potential risks of using chloroquine/hydroxychloroquine based treatments for COVID-19. medRxiv. 2020 Jun 02. PMID: 32577690; PMCID: PMC7302299.
      Citations:    
    23. Othman H, Bouslama Z, Brandenburg JT, da Rocha J, Hamdi Y, Ghedira K, Srairi-Abid N, Hazelhurst S. Interaction of the spike protein RBD from SARS-CoV-2 with ACE2: Similarity with SARS-CoV, hot-spot analysis and effect of the receptor polymorphism. Biochem Biophys Res Commun. 2020 06 30; 527(3):702-708. PMID: 32410735; PMCID: PMC7221370.
      Citations: 84     Fields:    Translation:HumansCellsPHPublic Health
    24. BenAissa R, Othman H, Villard C, Peigneur S, Mlayah-Bellalouna S, Abdelkafi-Koubaa Z, Marrakchi N, Essafi-Benkhadir K, Tytgat J, Luis J, Srairi-Abid N. AaHIV a sodium channel scorpion toxin inhibits the proliferation of DU145 prostate cancer cells. Biochem Biophys Res Commun. 2020 01 08; 521(2):340-346. PMID: 31668811.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    25. Benabdessalem C, Othman H, Ouni R, Ghouibi N, Dahman A, Riahi R, Larguach B, Srairi-Abid N, Barbouche MR, Fathallah MD. N-glycosylation and homodimeric folding significantly enhance the immunoreactivity of Mycobacterium tuberculosis virulence factor CFP32 when produced in the yeast Pichia pastoris. Biochem Biophys Res Commun. 2019 08 27; 516(3):845-850. PMID: 31262446.
      Citations:    Fields:    Translation:AnimalsCells
    26. Srairi-Abid N, Othman H, Aissaoui D, BenAissa R. Anti-tumoral effect of scorpion peptides: Emerging new cellular targets and signaling pathways. Cell Calcium. 2019 06; 80:160-174. PMID: 31108338.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    27. Riahi-Chebbi I, Souid S, Othman H, Haoues M, Karoui H, Morel A, Srairi-Abid N, Essafi M, Essafi-Benkhadir K. The Phenolic compound Kaempferol overcomes 5-fluorouracil resistance in human resistant LS174 colon cancer cells. Sci Rep. 2019 01 17; 9(1):195. PMID: 30655588; PMCID: PMC6336835.
      Citations: 51     Fields:    Translation:HumansCells
    28. Khamessi O, Ben Mabrouk H, Othman H, ElFessi-Magouri R, De Waard M, Hafedh M, Marrakchi N, Srairi-Abid N, Kharrat R. RK, the first scorpion peptide with dual disintegrin activity on a1ß1 and avß3 integrins. Int J Biol Macromol. 2018 Dec; 120(Pt B):1777-1788. PMID: 30287364.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    29. Ellijimi C, Ben Hammouda M, Othman H, Moslah W, Jebali J, Mabrouk HB, Morjen M, Haoues M, Luis J, Marrakchi N, Essafi-Benkhadir K, Srairi-Abid N. Helix aspersa maxima mucus exhibits antimelanogenic and antitumoral effects against melanoma cells. Biomed Pharmacother. 2018 May; 101:871-880. PMID: 29635896.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    30. Aissaoui D, Mlayah-Bellalouna S, Jebali J, Abdelkafi-Koubaa Z, Souid S, Moslah W, Othman H, Luis J, ElAyeb M, Marrakchi N, Essafi-Benkhadir K, Srairi-Abid N. Functional role of Kv1.1 and Kv1.3 channels in the neoplastic progression steps of three cancer cell lines, elucidated by scorpion peptides. Int J Biol Macromol. 2018 May; 111:1146-1155. PMID: 29415410.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    31. Hammouda MB, Riahi-Chebbi I, Souid S, Othman H, Aloui Z, Srairi-Abid N, Karoui H, Gasmi A, Magnenat EM, Wells TNC, Clemetson KJ, Rodríguez-López JN, Essafi-Benkhadir K. Macrovipecetin, a C-type lectin from Macrovipera lebetina venom, inhibits proliferation migration and invasion of SK-MEL-28 human melanoma cells and enhances their sensitivity to cisplatin. Biochim Biophys Acta Gen Subj. 2018 Mar; 1862(3):600-614. PMID: 29196192.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    32. Smichi N, Othman H, Achouri N, Noiriel A, Triki S, Arondel V, Srairi-Abid N, Abousalham A, Gargouri Y, Miled N, Fendri A. Efficient heterologous expression, functional characterization and molecular modeling of annular seabream digestive phospholipase A2. Chem Phys Lipids. 2018 03; 211:16-29. PMID: 28624308.
      Citations:    Fields:    Translation:Animals
    33. Smichi N, Othman H, Achouri N, Noiriel A, Arondel V, Srairi-Abid N, Abousalham A, Gargouri Y, Miled N, Fendri A. Functional and Structural Characterization of a Thermostable Phospholipase A2 from a Sparidae Fish (Diplodus annularis). J Agric Food Chem. 2017 Mar 22; 65(11):2468-2480. PMID: 28287729.
      Citations:    Fields:    Translation:AnimalsCells
    34. Othman H, Wieninger SA, ElAyeb M, Nilges M, Srairi-Abid N. In Silico prediction of the molecular basis of ClTx and AaCTx interaction with matrix metalloproteinase-2 (MMP-2) to inhibit glioma cell invasion. J Biomol Struct Dyn. 2017 Oct; 35(13):2815-2829. PMID: 27678152.
      Citations: 6     Fields:    Translation:HumansCells
    35. Baîram D, Aissa I, Louati H, Othman H, Abdelkafi-Koubaa Z, Krayem N, El Ayeb M, Srairi-Abid N, Marrakchi N, Gargouri Y. Biochemical and monolayer characterization of Tunisian snake venom phospholipases. Int J Biol Macromol. 2016 Aug; 89:640-6. PMID: 27164498.
      Citations: 2     Fields:    Translation:AnimalsCells
    36. Zakraoui O, Marcinkiewicz C, Aloui Z, Othman H, Grépin R, Haoues M, Essafi M, Srairi-Abid N, Gasmi A, Karoui H, Pagès G, Essafi-Benkhadir K. Lebein, a snake venom disintegrin, suppresses human colon cancer cells proliferation and tumor-induced angiogenesis through cell cycle arrest, apoptosis induction and inhibition of VEGF expression. Mol Carcinog. 2017 01; 56(1):18-35. PMID: 26824338.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    37. ElFessi-Magouri R, Peigneur S, Othman H, Srairi-Abid N, ElAyeb M, Tytgat J, Kharrat R. Characterization of Kbot21 Reveals Novel Side Chain Interactions of Scorpion Toxins Inhibiting Voltage-Gated Potassium Channels. PLoS One. 2015; 10(9):e0137611. PMID: 26398235; PMCID: PMC4580410.
      Citations: 3     Fields:    Translation:AnimalsCells
    38. Refai A, Haoues M, Othman H, Barbouche MR, Moua P, Bondon A, Mouret L, Srairi-Abid N, Essafi M. Two distinct conformational states of Mycobacterium tuberculosis virulent factor early secreted antigenic target 6 kDa are behind the discrepancy around its biological functions. FEBS J. 2015 Nov; 282(21):4114-29. PMID: 26260636.
      Citations: 16     Fields:    Translation:HumansCells
    39. Jallouli R, Othman H, Amara S, Parsiegla G, Carriere F, Srairi-Abid N, Gargouri Y, Bezzine S. The galactolipase activity of Fusarium solani (phospho)lipase. Biochim Biophys Acta. 2015 Mar; 1851(3):282-9. PMID: 25529980.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    40. Mlayah-Bellalouna S, Dufour M, Mabrouk K, Mejdoub H, Carlier E, Othman H, Belghazi M, Tarbe M, Goaillard JM, Gigmes D, Seagar M, El Ayeb M, Debanne D, Srairi-Abid N. AaTX1, from Androctonus australis scorpion venom: purification, synthesis and characterization in dopaminergic neurons. Toxicon. 2014 Dec 15; 92:14-23. PMID: 25240295.
      Citations: 6     Fields:    Translation:AnimalsCells
    41. Abdelkafi-Koubaa Z, Jebali J, Othman H, Morjen M, Aissa I, Zouari-Kesentini R, Bazaa A, Ellefi AA, Majdoub H, Srairi-Abid N, Gargouri Y, El Ayeb M, Marrakchi N. A thermoactive L-amino acid oxidase from Cerastes cerastes snake venom: purification, biochemical and molecular characterization. Toxicon. 2014 Oct; 89:32-44. PMID: 25009089.
      Citations: 6     Fields:    Translation:Cells
    42. Morjen M, Kallech-Ziri O, Bazaa A, Othman H, Mabrouk K, Zouari-Kessentini R, Sanz L, Calvete JJ, Srairi-Abid N, El Ayeb M, Luis J, Marrakchi N. PIVL, a new serine protease inhibitor from Macrovipera lebetina transmediterranea venom, impairs motility of human glioblastoma cells. Matrix Biol. 2013 Jan; 32(1):52-62. PMID: 23262217.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
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