Cytochrome P-450 Enzyme System
"Cytochrome P-450 Enzyme System" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.
| Descriptor ID |
D003577
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| MeSH Number(s) |
D08.244.453 D08.811.682.690.708.170 D12.776.422.220.453
|
| Concept/Terms |
Cytochrome P-450 Enzyme System- Cytochrome P-450 Enzyme System
- Cytochrome P 450 Enzyme System
- Cytochrome P450
- P-450 Enzymes
- Enzymes, P-450
- P 450 Enzymes
- P450 Enzymes
- Enzymes, P450
- CYP450 Family
- Cytochrome P450 Superfamily
- Superfamily, Cytochrome P450
- Cytochrome P-450 Superfamily
- Cytochrome P 450 Superfamily
- Superfamily, Cytochrome P-450
- Cytochrome p450 Families
- Cytochrome P-450 Families
- Cytochrome P 450 Families
- CYP450 Superfamily
- Superfamily, CYP450
- Cytochrome P-450
- Cytochrome P 450
- Cytochrome P-450 Enzymes
- Cytochrome P 450 Enzymes
- Enzymes, Cytochrome P-450
- P-450 Enzymes, Cytochrome
Cytochrome P-450 Monooxygenase- Cytochrome P-450 Monooxygenase
- Cytochrome P 450 Monooxygenase
- Monooxygenase, Cytochrome P-450
- Cytochrome P-450-Dependent Monooxygenase
- Cytochrome P 450 Dependent Monooxygenase
- Monooxygenase, Cytochrome P-450-Dependent
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Below are MeSH descriptors whose meaning is more general than "Cytochrome P-450 Enzyme System".
Below are MeSH descriptors whose meaning is more specific than "Cytochrome P-450 Enzyme System".
This graph shows the total number of publications written about "Cytochrome P-450 Enzyme System" by people in this website by year, and whether "Cytochrome P-450 Enzyme System" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 0 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 1 | 0 | 1 |
| 2006 | 1 | 0 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
| 2021 | 1 | 1 | 2 |
| 2023 | 2 | 0 | 2 |
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Below are the most recent publications written about "Cytochrome P-450 Enzyme System" by people in Profiles.
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The African Liver Tissue Biorepository Consortium: Capacitating Population-Appropriate Drug Metabolism, Pharmacokinetics, and Pharmacogenetics Research in Drug Discovery and Development. Drug Metab Dispos. 2023 Dec; 51(12):1551-1560.
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Characterizing the combined effects of cytochrome P450 missense variation within star allele definitions. Pharmacogenomics. 2023 07; 24(10):561-578.
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StellarPGx: A Nextflow Pipeline for Calling Star Alleles in Cytochrome P450 Genes. Clin Pharmacol Ther. 2021 09; 110(3):741-749.
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Association of Rare CYP39A1 Variants With Exfoliation Syndrome Involving the Anterior Chamber of the Eye. JAMA. 2021 02 23; 325(8):753-764.
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Cross-resistance profiles of malaria mosquito P450s associated with pyrethroid resistance against WHO insecticides. Pestic Biochem Physiol. 2019 Nov; 161:61-67.
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The effects of ingestion of hormonal host factors on the longevity and insecticide resistance phenotype of the major malaria vector Anopheles arabiensis (Diptera: Culicidae). PLoS One. 2017; 12(7):e0180909.
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Simultaneous Emergence of Multidrug-Resistant Candida auris on 3 Continents Confirmed by Whole-Genome Sequencing and Epidemiological Analyses. Clin Infect Dis. 2017 Jan 15; 64(2):134-140.
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DDT and pyrethroid resistance in Anopheles arabiensis from South Africa. Parasit Vectors. 2013 Aug 08; 6(1):229.
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Age-related pyrethroid resistance is not a function of P450 gene expression in the major African malaria vector, Anopheles funestus (Diptera: Culicidae). Genet Mol Res. 2011 Dec 21; 10(4):3220-9.
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Sequence characterization of cytochrome P450 CYP6P9 in pyrethroid resistant and susceptible Anopheles funestus (Diptera: Culicidae). Genet Mol Res. 2010 Mar 30; 9(1):554-64.