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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Abkallo HM, Arbuthnot P, Auer TO, Berger DK, Burger J, Chakauya E, Concordet JP, Diabate A, Di Donato V, Groenewald JH, Guindo A, Koekemoer LL, Nazare F, Nolan T, Okumu F, Orefuwa E, Paemka L, Prieto-Godino L, Runo S, Sadler M, Tesfaye K, Tripathi L, Wondji C. Making genome editing a success story in Africa. Nat Biotechnol. 2024 Apr; 42(4):551-554. PMID: 38504013.
      Citations:    Fields:    
    2. Jacobs R, Dogbey MD, Mnyandu N, Neves K, Barth S, Arbuthnot P, Maepa MB. AAV Immunotoxicity: Implications in Anti-HBV Gene Therapy. Microorganisms. 2023 Dec 14; 11(12). PMID: 38138129; PMCID: PMC10745739.
      Citations: 1     
    3. Kana BD, Arbuthnot P, Botwe BK, Choonara YE, Hassan F, Louzir H, Matsoso P, Moore PL, Muhairwe A, Naidoo K, Ndomondo-Sigonda M, Madhi SA. Opportunities and challenges of leveraging COVID-19 vaccine innovation and technologies for developing sustainable vaccine manufacturing capabilities in Africa. Lancet Infect Dis. 2023 08; 23(8):e288-e300. PMID: 37290473.
      Citations: 3     Fields:    Translation:HumansPHPublic Health
    4. Kairuz D, Samudh N, Ely A, Arbuthnot P, Bloom K. Production, Characterization, and Assessment of Permanently Cationic and Ionizable Lipid Nanoparticles for Use in the Delivery of Self-Amplifying RNA Vaccines. Pharmaceutics. 2023 Apr 07; 15(4). PMID: 37111658; PMCID: PMC10143526.
      Citations: 2     
    5. Farhad T, Neves K, Arbuthnot P, Maepa MB. Adenoviral Vectors: Potential as Anti-HBV Vaccines and Therapeutics. Genes (Basel). 2022 10 25; 13(11). PMID: 36360178; PMCID: PMC9689594.
      Citations: 3     Fields:    Translation:HumansCells
    6. Kairuz D, Samudh N, Ely A, Arbuthnot P, Bloom K. Advancing mRNA technologies for therapies and vaccines: An African context. Front Immunol. 2022; 13:1018961. PMID: 36353641; PMCID: PMC9637871.
      Citations: 4     Fields:    Translation:Humans
    7. Maepa MB, Ely A, Kramvis A, Bloom K, Naidoo K, Simani OE, Maponga TG, Arbuthnot P. Hepatitis B Virus Research in South Africa. Viruses. 2022 08 31; 14(9). PMID: 36146747; PMCID: PMC9503375.
      Citations: 9     Fields:    Translation:HumansCells
    8. Jacobs R, Singh P, Smith T, Arbuthnot P, Maepa MB. Prospects of viral vector-mediated delivery of sequences encoding anti-HBV designer endonucleases. Gene Ther. 2022 May 24. PMID: 35606493.
      Citations: 2     Fields:    
    9. Samudh N, Shrilall C, Arbuthnot P, Bloom K, Ely A. Diversity of Dysregulated Long Non-Coding RNAs in HBV-Related Hepatocellular Carcinoma. Front Immunol. 2022; 13:834650. PMID: 35154157; PMCID: PMC8831247.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    10. Mnyandu N, Limani SW, Arbuthnot P, Maepa MB. Advances in designing Adeno-associated viral vectors for development of anti-HBV gene therapeutics. Virol J. 2021 12 13; 18(1):247. PMID: 34903258; PMCID: PMC8670254.
      Citations: 3     Fields:    Translation:AnimalsCells
    11. Limani SW, Mnyandu N, Ely A, Wadee R, Kramvis A, Arbuthnot P, Maepa MB. In Vivo Modelling of Hepatitis B Virus Subgenotype A1 Replication Using Adeno-Associated Viral Vectors. Viruses. 2021 11 09; 13(11). PMID: 34835053; PMCID: PMC8618177.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    12. Smith T, Singh P, Chmielewski KO, Bloom K, Cathomen T, Arbuthnot P, Ely A. Improved Specificity and Safety of Anti-Hepatitis B Virus TALENs Using Obligate Heterodimeric FokI Nuclease Domains. Viruses. 2021 07 12; 13(7). PMID: 34372550; PMCID: PMC8310341.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    13. Singh P, Kairuz D, Arbuthnot P, Bloom K. Silencing hepatitis B virus covalently closed circular DNA: The potential of an epigenetic therapy approach. World J Gastroenterol. 2021 Jun 21; 27(23):3182-3207. PMID: 34163105; PMCID: PMC8218364.
      Citations: 5     Fields:    Translation:HumansCells
    14. Maepa MB, Bloom K, Ely A, Arbuthnot P. Hepatitis B virus: promising drug targets and therapeutic implications. Expert Opin Ther Targets. 2021 06; 25(6):451-466. PMID: 33843412.
      Citations: 3     Fields:    Translation:HumansCells
    15. Mosti L, Langner LM, Chmielewski KO, Arbuthnot P, Alzubi J, Cathomen T. Targeted multi-epitope switching enables straightforward positive/negative selection of CAR T cells. Gene Ther. 2021 09; 28(9):602-612. PMID: 33526841; PMCID: PMC8455323.
      Citations: 6     Fields:    Translation:HumansCells
    16. Ely A, Bloom K, Maepa MB, Arbuthnot P. Recent Update on the Role of Circular RNAs in Hepatocellular Carcinoma. J Hepatocell Carcinoma. 2021; 8:1-17. PMID: 33542907; PMCID: PMC7851377.
      Citations: 5     
    17. Bloom K, van den Berg F, Arbuthnot P. Self-amplifying RNA vaccines for infectious diseases. Gene Ther. 2021 Apr; 28(3-4):117-129. PMID: 33093657; PMCID: PMC7580817.
      Citations: 147     Fields:    Translation:HumansCellsPHPublic Health
    18. van den Berg F, Limani SW, Mnyandu N, Maepa MB, Ely A, Arbuthnot P. Advances with RNAi-Based Therapy for Hepatitis B Virus Infection. Viruses. 2020 08 04; 12(8). PMID: 32759756; PMCID: PMC7472220.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    19. Ely A, Singh P, Smith TS, Arbuthnot P. In vitro transcribed mRNA for expression of designer nucleases: Advantages as a novel therapeutic for the management of chronic HBV infection. Adv Drug Deliv Rev. 2021 01; 168:134-146. PMID: 32485207.
      Citations: 8     Fields:    Translation:Cells
    20. Maepa MB, Jacobs R, van den Berg F, Arbuthnot P. Recent developments with advancing gene therapy to treat chronic infection with hepatitis B virus. Curr Opin HIV AIDS. 2020 05; 15(3):200-207. PMID: 32141890.
      Citations: 5     Fields:    Translation:HumansCells
    21. Mnyandu N, Arbuthnot P, Maepa MB. In Vivo Delivery of Cassettes Encoding Anti-HBV Primary MicroRNAs Using an Ancestral Adeno-Associated Viral Vector. Methods Mol Biol. 2020; 2115:171-183. PMID: 32006401.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    22. van den Berg FT, Ely A, Arbuthnot P. Generating DNA Expression Cassettes Encoding Multimeric Artificial MicroRNA Precursors. Methods Mol Biol. 2020; 2115:185-197. PMID: 32006402.
      Citations:    Fields:    Translation:HumansCells
    23. Paximadis M, Perez Patrigeon S, Rajasuriar R, Tatoud R, Scully E, Arbuthnot P. Hepatitis B and HIV-1 2019 IAS Cure Forum: lessons and benefits from interdisciplinary research. J Virus Erad. 2019 Nov 04; 5(4):234-244. PMID: 31754448; PMCID: PMC6844409.
      Citations:    
    24. Bloom K, Kaldine H, Cathomen T, Mussolino C, Ely A, Arbuthnot P. Inhibition of replication of hepatitis B virus using transcriptional repressors that target the viral DNA. BMC Infect Dis. 2019 Sep 12; 19(1):802. PMID: 31510934; PMCID: PMC6739920.
      Citations: 8     Fields:    Translation:AnimalsCells
    25. Ely A, Bloom K, Maepa MB, Mahlangu JN, Pepper MS, Arbuthnot P. Gene and cell therapy in South Africa: Current status and future prospects. S Afr Med J. 2019 Sep 10; 109(8b):12-16. PMID: 31662143.
      Citations: 1     Fields:    Translation:HumansAnimals
    26. van den Berg FT, Makoah NA, Ali SA, Scott TA, Mapengo RE, Mutsvunguma LZ, Mkhize NN, Lambson BE, Kgagudi PD, Crowther C, Abdool Karim SS, Balazs AB, Weinberg MS, Ely A, Arbuthnot PB, Morris L. AAV-Mediated Expression of Broadly Neutralizing and Vaccine-like Antibodies Targeting the HIV-1 Envelope V2 Region. Mol Ther Methods Clin Dev. 2019 Sep 13; 14:100-112. PMID: 31334303; PMCID: PMC6616373.
      Citations: 19     
    27. Arbuthnot P, Ely A, Bloom K. A convenient method to generate and maintain poly(A)-encoding DNA sequences required for in vitro transcription of mRNA. Biotechniques. 2019 01; 66(1):37-39. PMID: 30730207.
      Citations: 3     Fields:    Translation:Cells
    28. Bloom K, Maepa MB, Ely A, Arbuthnot P. Gene Therapy for Chronic HBV-Can We Eliminate cccDNA? Genes (Basel). 2018 Apr 12; 9(4). PMID: 29649127; PMCID: PMC5924549.
      Citations: 31     Fields:    
    29. Maepa MB, Ely A, Arbuthnot P. How successful has targeted RNA interference for hepatic fibrosis been? Expert Opin Biol Ther. 2018 04; 18(4):381-388. PMID: 29265946.
      Citations: 2     Fields:    Translation:HumansCells
    30. Scott T, Moyo B, Nicholson S, Maepa MB, Watashi K, Ely A, Weinberg MS, Arbuthnot P. ssAAVs containing cassettes encoding SaCas9 and guides targeting hepatitis B virus inactivate replication of the virus in cultured cells. Sci Rep. 2017 08 07; 7(1):7401. PMID: 28785016; PMCID: PMC5547162.
      Citations: 36     Fields:    Translation:HumansCells
    31. Arbuthnot P, Maepa MB, Ely A, Pepper MS. The state of gene therapy research in Africa, its significance and implications for the future. Gene Ther. 2017 09; 24(9):581-589. PMID: 28692018; PMCID: PMC7094717.
      Citations: 5     Fields:    Translation:Humans
    32. Maepa MB, Ely A, Grayson W, Arbuthnot P. Sustained Inhibition of HBV Replication In Vivo after Systemic Injection of AAVs Encoding Artificial Antiviral Primary MicroRNAs. Mol Ther Nucleic Acids. 2017 Jun 16; 7:190-199. PMID: 28624194; PMCID: PMC5415967.
      Citations: 14     
    33. Delhove JM, Buckley SM, Perocheau DP, Karda R, Arbuthnot P, Henderson NC, Waddington SN, McKay TR. Longitudinal in vivo bioimaging of hepatocyte transcription factor activity following cholestatic liver injury in mice. Sci Rep. 2017 02 03; 7:41874. PMID: 28157201; PMCID: PMC5291111.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    34. Moyo B, Bloom K, Scott T, Ely A, Arbuthnot P. Advances with using CRISPR/Cas-mediated gene editing to treat infections with hepatitis B virus and hepatitis C virus. Virus Res. 2018 01 15; 244:311-320. PMID: 28087399.
      Citations: 31     Fields:    Translation:HumansCells
    35. Bloom K, Ely A, Arbuthnot P. A T7 Endonuclease I Assay to Detect Talen-Mediated Targeted Mutation of HBV cccDNA. Methods Mol Biol. 2017; 1540:85-95. PMID: 27975310.
      Citations: 6     Fields:    Translation:HumansCells
    36. Lamb C, Arbuthnot P. Activating the innate immune response to counter chronic hepatitis B virus infection. Expert Opin Biol Ther. 2016 12; 16(12):1517-1527. PMID: 27603796.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    37. Dreyer T, Nicholson S, Ely A, Arbuthnot P, Bloom K. Improved antiviral efficacy using TALEN-mediated homology directed recombination to introduce artificial primary miRNAs into DNA of hepatitis B virus. Biochem Biophys Res Commun. 2016 09 30; 478(4):1563-8. PMID: 27590580.
      Citations: 17     Fields:    Translation:HumansCells
    38. Bourhill T, Arbuthnot P, Ely A. Successful disabling of the 5' UTR of HCV using adeno-associated viral vectors to deliver modular multimeric primary microRNA mimics. J Virol Methods. 2016 09; 235:26-33. PMID: 27181212.
      Citations: 6     Fields:    Translation:HumansCells
    39. Ely A, Moyo B, Arbuthnot P. Progress With Developing Use of Gene Editing To Cure Chronic Infection With Hepatitis B Virus. Mol Ther. 2016 Apr; 24(4):671-7. PMID: 26916283; PMCID: PMC4886943.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    40. van den Berg FT, Rossi JJ, Arbuthnot P, Weinberg MS. Design of Effective Primary MicroRNA Mimics With Different Basal Stem Conformations. Mol Ther Nucleic Acids. 2016 Jan 12; 5:e278. PMID: 26756196; PMCID: PMC5012551.
      Citations: 3     
    41. Mbatha L, Chakravorty S, de Koning CB, van Otterlo WA, Arbuthnot P, Ariatti M, Singh M. Spacer Length: A Determining Factor in the Design of Galactosyl Ligands for Hepatoma Cell-Specific Liposomal Gene Delivery. Curr Drug Deliv. 2016; 13(6):935-45. PMID: 26906564.
      Citations: 3     Fields:    Translation:HumansCells
    42. Crowther C, Mowa B, Arbuthnot P. Hepatic Delivery of Artificial Micro RNAs Using Helper-Dependent Adenoviral Vectors. Methods Mol Biol. 2016; 1364:249-60. PMID: 26472456.
      Citations: 2     Fields:    Translation:AnimalsCells
    43. Ely A, Arbuthnot P. Differing prospects for the future of using gene therapy to treat infections with hepatitis B virus and hepatitis C virus. Discov Med. 2015 Sep; 20(109):137-43. PMID: 26463095.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    44. Moyo B, Nicholson SA, Arbuthnot PB. The role of long non-coding RNAs in hepatitis B virus-related hepatocellular carcinoma. Virus Res. 2016 Jan 02; 212:103-13. PMID: 26239319.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    45. Maepa MB, Roelofse I, Ely A, Arbuthnot P. Progress and Prospects of Anti-HBV Gene Therapy Development. Int J Mol Sci. 2015 Jul 31; 16(8):17589-610. PMID: 26263978; PMCID: PMC4581210.
      Citations: 16     Fields:    Translation:HumansCells
    46. Buckley SM, Delhove JM, Perocheau DP, Karda R, Rahim AA, Howe SJ, Ward NJ, Birrell MA, Belvisi MG, Arbuthnot P, Johnson MR, Waddington SN, McKay TR. In vivo bioimaging with tissue-specific transcription factor activated luciferase reporters. Sci Rep. 2015 Jul 03; 5:11842. PMID: 26138224; PMCID: PMC4490336.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    47. Marimani MD, Ely A, Buff MC, Bernhardt S, Engels JW, Scherman D, Escriou V, Arbuthnot P. Inhibition of replication of hepatitis B virus in transgenic mice following administration of hepatotropic lipoplexes containing guanidinopropyl-modified siRNAs. J Control Release. 2015 Jul 10; 209:198-206. PMID: 25937322.
      Citations: 12     Fields:    Translation:AnimalsCells
    48. Nicholson SA, Moyo B, Arbuthnot PB. Progress and prospects of engineered sequence-specific DNA modulating technologies for the management of liver diseases. World J Hepatol. 2015 Apr 28; 7(6):859-73. PMID: 25937863; PMCID: PMC4411528.
      Citations: 4     
    49. Rey ME, Harmse J, Taylor SH, Arbuthnot P, Weinberg MS. Construction of mismatched inverted repeat (IR) silencing vectors for maximizing IR stability and effective gene silencing in plants. Methods Mol Biol. 2015; 1287:295-304. PMID: 25740374.
      Citations:    Fields:    Translation:AnimalsCells
    50. Bloom K, Ely A, Arbuthnot P. Recent advances in use of gene therapy to treat hepatitis B virus infection. Adv Exp Med Biol. 2015; 848:31-49. PMID: 25757614.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    51. Buff MC, Bernhardt S, Marimani MD, Ely A, Engels JW, Arbuthnot P. Use of guanidinopropyl-modified siRNAs to silence gene expression. Methods Mol Biol. 2015; 1218:217-49. PMID: 25319654.
      Citations:    Fields:    Translation:HumansCells
    52. Govender D, Islam RU, De Koning CB, van Otterlo WA, Arbuthnot P, Ariatti M, Singh M. Stealth lipoplex decorated with triazole-tethered galactosyl moieties: a strong hepatotropic gene vector. Biotechnol Lett. 2015 Mar; 37(3):567-75. PMID: 25432417.
      Citations: 1     Fields:    Translation:HumansCells
    53. Ivacik D, Ely A, Ferry N, Arbuthnot P. Sustained inhibition of hepatitis B virus replication in vivo using RNAi-activating lentiviruses. Gene Ther. 2015 Feb; 22(2):163-71. PMID: 25338920.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    54. Mowa MB, Crowther C, Ely A, Arbuthnot P. Inhibition of hepatitis B virus replication by helper dependent adenoviral vectors expressing artificial anti-HBV pri-miRs from a liver-specific promoter. Biomed Res Int. 2014; 2014:718743. PMID: 25003129; PMCID: PMC4066856.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    55. Crowther C, Mowa MB, Ely A, Arbuthnot PB. Inhibition of HBV replication in vivo using helper-dependent adenovirus vectors to deliver antiviral RNA interference expression cassettes. Antivir Ther. 2014; 19(4):363-73. PMID: 24296696.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    56. Marimani M, Hean J, Bloom K, Ely A, Arbuthnot P. Recent advances in developing nucleic acid-based HBV therapy. Future Microbiol. 2013 Nov; 8(11):1489-504. PMID: 24199806.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    57. Bloom K, Ely A, Mussolino C, Cathomen T, Arbuthnot P. Inactivation of hepatitis B virus replication in cultured cells and in vivo with engineered transcription activator-like effector nucleases. Mol Ther. 2013 Oct; 21(10):1889-97. PMID: 23883864; PMCID: PMC3808145.
      Citations: 95     Fields:    Translation:HumansAnimalsCells
    58. Marimani MD, Ely A, Buff MC, Bernhardt S, Engels JW, Arbuthnot P. Inhibition of hepatitis B virus replication in cultured cells and in vivo using 2'-O-guanidinopropyl modified siRNAs. Bioorg Med Chem. 2013 Oct 15; 21(20):6145-55. PMID: 23743442.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    59. Pichard V, Aubert D, Boni S, Battaglia S, Ivacik D, Nguyen TH, Arbuthnot P, Ferry N. Specific micro RNA-regulated TetR-KRAB transcriptional control of transgene expression in viral vector-transduced cells. PLoS One. 2012; 7(12):e51952. PMID: 23251659; PMCID: PMC3522580.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    60. Green VA, Arbuthnot P, Weinberg MS. Impact of sustained RNAi-mediated suppression of cellular cofactor Tat-SF1 on HIV-1 replication in CD4+ T cells. Virol J. 2012 Nov 15; 9:272. PMID: 23153325; PMCID: PMC3511259.
      Citations: 4     Fields:    Translation:HumansCells
    61. Taylor SH, Harmse J, Arbuthnot P, Van Den Berg F, Weinberg MS, Rey ME. Construction of effective inverted repeat silencing constructs using sodium bisulfite treatment coupled with strand-specific PCR. Biotechniques. 2012 Apr; 52(4):254-62. PMID: 22482441.
      Citations: 1     Fields:    Translation:AnimalsCells
    62. Scott T, Paweska JT, Arbuthnot P, Weinberg MS. Pathogenic effects of Rift Valley fever virus NSs gene are alleviated in cultured cells by expressed antiviral short hairpin RNAs. Antivir Ther. 2012; 17(4):643-56. PMID: 22345363.
      Citations: 5     Fields:    Translation:HumansCells
    63. Mowa MB, Crowther C, Ely A, Arbuthnot P. Efficient silencing of hepatitis B virus by helper-dependent adenovirus vector-mediated delivery of artificial antiviral primary micro RNAs. Microrna. 2012; 1(1):19-25. PMID: 25048086.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    64. Brzezinska J, D'Onofrio J, Buff MC, Hean J, Ely A, Marimani M, Arbuthnot P, Engels JW. Synthesis of 2'-O-guanidinopropyl-modified nucleoside phosphoramidites and their incorporation into siRNAs targeting hepatitis B virus. Bioorg Med Chem. 2012 Feb 15; 20(4):1594-606. PMID: 22264759.
      Citations: 5     Fields:    Translation:HumansCells
    65. Ivacik D, Ely A, Arbuthnot P. Countering hepatitis B virus infection using RNAi: how far are we from the clinic? Rev Med Virol. 2011 Nov; 21(6):383-96. PMID: 21913277.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    66. Arbuthnot P. MicroRNA-like antivirals. Biochim Biophys Acta. 2011 Nov-Dec; 1809(11-12):746-55. PMID: 21616187.
      Citations: 4     Fields:    Translation:HumansAnimals
    67. Mowa MB, Crowther C, Arbuthnot P. Therapeutic potential of adenoviral vectors for delivery of expressed RNAi activators. Expert Opin Drug Deliv. 2010 Dec; 7(12):1373-85. PMID: 21073358.
      Citations: 13     Fields:    Translation:HumansCells
    68. Hean J, Crowther C, Ely A, Ul Islam R, Barichievy S, Bloom K, Weinberg MS, van Otterlo WA, de Koning CB, Salazar F, Marion P, Roesch EB, Lemaitre M, Herdewijn P, Arbuthnot P. Inhibition of hepatitis B virus replication in vivo using lipoplexes containing altritol-modified antiviral siRNAs. Artif DNA PNA XNA. 2010 Jul; 1(1):17-26. PMID: 21687523; PMCID: PMC3109439.
      Citations: 12     Fields:    
    69. Dyer V, Ely A, Bloom K, Weinberg M, Arbuthnot P. tRNA Lys3 promoter cassettes that efficiently express RNAi-activating antihepatitis B virus short hairpin RNAs. Biochem Biophys Res Commun. 2010 Aug 06; 398(4):640-6. PMID: 20599752.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    70. Arbuthnot P. Harnessing RNA interference for the treatment of viral infections. Drug News Perspect. 2010 Jul-Aug; 23(6):341-50. PMID: 20697601.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    71. Saayman S, Arbuthnot P, Weinberg MS. Deriving four functional anti-HIV siRNAs from a single Pol III-generated transcript comprising two adjacent long hairpin RNA precursors. Nucleic Acids Res. 2010 Oct; 38(19):6652-63. PMID: 20525791; PMCID: PMC2965221.
      Citations: 10     Fields:    Translation:HumansCells
    72. Weinberg MS, Arbuthnot P. Progress in the use of RNA interference as a therapy for chronic hepatitis B virus infection. Genome Med. 2010 Apr 28; 2(4):28. PMID: 20429960; PMCID: PMC2873806.
      Citations: 6     Fields:    
    73. Saayman SM, Arbuthnot P, Weinberg MS. Effective Pol III-expressed long hairpin RNAs targeted to multiple unique sites of HIV-1. Methods Mol Biol. 2010; 629:159-74. PMID: 20387149.
      Citations: 2     Fields:    Translation:HumansCells
    74. Mével M, Kamaly N, Carmona S, Oliver MH, Jorgensen MR, Crowther C, Salazar FH, Marion PL, Fujino M, Natori Y, Thanou M, Arbuthnot P, Yaouanc JJ, Jaffrès PA, Miller AD. DODAG; a versatile new cationic lipid that mediates efficient delivery of pDNA and siRNA. J Control Release. 2010 Apr 19; 143(2):222-32. PMID: 19969034.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    75. Liu J, Ahiekpor A, Li L, Li X, Arbuthnot P, Kew M, Feitelson MA. Increased expression of ErbB-2 in liver is associated with hepatitis B x antigen and shorter survival in patients with liver cancer. Int J Cancer. 2009 Oct 15; 125(8):1894-901. PMID: 19610068; PMCID: PMC2745322.
      Citations: 19     Fields:    Translation:Humans
    76. Scholefield J, Greenberg LJ, Weinberg MS, Arbuthnot PB, Abdelgany A, Wood MJ. Design of RNAi hairpins for mutation-specific silencing of ataxin-7 and correction of a SCA7 phenotype. PLoS One. 2009 Sep 30; 4(9):e7232. PMID: 19789634; PMCID: PMC2747278.
      Citations: 29     Fields:    Translation:Humans
    77. Chattopadhyay S, Ely A, Bloom K, Weinberg MS, Arbuthnot P. Inhibition of hepatitis B virus replication with linear DNA sequences expressing antiviral micro-RNA shuttles. Biochem Biophys Res Commun. 2009 Nov 20; 389(3):484-9. PMID: 19733548.
      Citations: 9     Fields:    Translation:HumansCells
    78. Ely A, Naidoo T, Arbuthnot P. Efficient silencing of gene expression with modular trimeric Pol II expression cassettes comprising microRNA shuttles. Nucleic Acids Res. 2009 Jul; 37(13):e91. PMID: 19474340; PMCID: PMC2715259.
      Citations: 31     Fields:    Translation:HumansCells
    79. Carmona S, Jorgensen MR, Kolli S, Crowther C, Salazar FH, Marion PL, Fujino M, Natori Y, Thanou M, Arbuthnot P, Miller AD. Controlling HBV replication in vivo by intravenous administration of triggered PEGylated siRNA-nanoparticles. Mol Pharm. 2009 May-Jun; 6(3):706-17. PMID: 19159285.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    80. Arbuthnot P, Ely A, Weinberg MS. Hepatic delivery of RNA interference activators for therapeutic application. Curr Gene Ther. 2009 Apr; 9(2):91-103. PMID: 19355867.
      Citations: 5     Fields:    Translation:HumansCells
    81. Barichievy S, Saayman S, Arbuthnot P, Weinberg MS. RNA interference-based gene expression strategies aimed at sustained therapeutic inhibition of HIV. Curr Top Med Chem. 2009; 9(12):1065-78. PMID: 19860707.
      Citations: 2     Fields:    Translation:Cells
    82. Islam RU, Hean J, van Otterlo WA, de Koning CB, Arbuthnot P. Efficient nucleic acid transduction with lipoplexes containing novel piperazine- and polyamine-conjugated cholesterol derivatives. Bioorg Med Chem Lett. 2009 Jan 01; 19(1):100-3. PMID: 19028097.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    83. Crowther C, Ely A, Hornby J, Mufamadi S, Salazar F, Marion P, Arbuthnot P. Efficient inhibition of hepatitis B virus replication in vivo, using polyethylene glycol-modified adenovirus vectors. Hum Gene Ther. 2008 Nov; 19(11):1325-31. PMID: 19848584.
      Citations: 11     Fields:    Translation:AnimalsCells
    84. Saayman S, Barichievy S, Capovilla A, Morris KV, Arbuthnot P, Weinberg MS. The efficacy of generating three independent anti-HIV-1 siRNAs from a single U6 RNA Pol III-expressed long hairpin RNA. PLoS One. 2008 Jul 02; 3(7):e2602. PMID: 18596982; PMCID: PMC2434202.
      Citations: 15     Fields:    Translation:HumansCells
    85. Ely A, Naidoo T, Mufamadi S, Crowther C, Arbuthnot P. Expressed anti-HBV primary microRNA shuttles inhibit viral replication efficiently in vitro and in vivo. Mol Ther. 2008 Jun; 16(6):1105-12. PMID: 18431360.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    86. Arbuthnot P, Thompson LJ. Harnessing the RNA interference pathway to advance treatment and prevention of hepatocellular carcinoma. World J Gastroenterol. 2008 Mar 21; 14(11):1670-81. PMID: 18350598; PMCID: PMC2695907.
      Citations: 11     Fields:    Translation:HumansAnimals
    87. Arbuthnot P, Longshaw V, Naidoo T, Weinberg MS. Opportunities for treating chronic hepatitis B and C virus infection using RNA interference. J Viral Hepat. 2007 Jul; 14(7):447-59. PMID: 17576386.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    88. Lian Z, Liu J, Wu M, Wang HY, Arbuthnot P, Kew M, Feitelson MA. Hepatitis B x antigen up-regulates vascular endothelial growth factor receptor 3 in hepatocarcinogenesis. Hepatology. 2007 Jun; 45(6):1390-9. PMID: 17539024.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    89. Weinberg MS, Ely A, Barichievy S, Crowther C, Mufamadi S, Carmona S, Arbuthnot P. Specific inhibition of HBV replication in vitro and in vivo with expressed long hairpin RNA. Mol Ther. 2007 Mar; 15(3):534-41. PMID: 17213835.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    90. Weinberg MS, Ely A, Passman M, Mufamadi SM, Arbuthnot P. Effective anti-hepatitis B virus hammerhead ribozymes derived from multimeric precursors. Oligonucleotides. 2007; 17(1):104-12. PMID: 17461767.
      Citations: 5     Fields:    Translation:HumansCells
    91. Barichievy S, Saayman S, von Eije KJ, Morris KV, Arbuthnot P, Weinberg MS. The inhibitory efficacy of RNA POL III-expressed long hairpin RNAs targeted to untranslated regions of the HIV-1 5' long terminal repeat. Oligonucleotides. 2007; 17(4):419-31. PMID: 17896874.
      Citations: 9     Fields:    Translation:HumansCells
    92. Cave E, Weinberg MS, Cilliers T, Carmona S, Morris L, Arbuthnot P. Silencing of HIV-1 subtype C primary isolates by expressed small hairpin RNAs targeted to gag. AIDS Res Hum Retroviruses. 2006 May; 22(5):401-10. PMID: 16706616.
      Citations: 6     Fields:    Translation:HumansCells
    93. Lian Z, Liu J, Li L, Li X, Clayton M, Wu MC, Wang HY, Arbuthnot P, Kew M, Fan D, Feitelson MA. Enhanced cell survival of Hep3B cells by the hepatitis B x antigen effector, URG11, is associated with upregulation of beta-catenin. Hepatology. 2006 Mar; 43(3):415-24. PMID: 16496348.
      Citations: 28     Fields:    Translation:HumansCells
    94. Liu J, Lian Z, Han S, Waye MM, Wang H, Wu MC, Wu K, Ding J, Arbuthnot P, Kew M, Fan D, Feitelson MA. Downregulation of E-cadherin by hepatitis B virus X antigen in hepatocellullar carcinoma. Oncogene. 2006 Feb 16; 25(7):1008-17. PMID: 16247464.
      Citations: 39     Fields:    Translation:HumansCells
    95. Carmona S, Ely A, Crowther C, Moolla N, Salazar FH, Marion PL, Ferry N, Weinberg MS, Arbuthnot P. Effective inhibition of HBV replication in vivo by anti-HBx short hairpin RNAs. Mol Ther. 2006 Feb; 13(2):411-21. PMID: 16337206.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    96. Arbuthnot P, Carmona S, Ely A. Exploiting the RNA interference pathway to counter hepatitis B virus replication. Liver Int. 2005 Feb; 25(1):9-15. PMID: 15698393.
      Citations: 12     Fields:    Translation:HumansCells
    97. Lian Z, Liu J, Li L, Li X, Tufan NL, Wu MC, Wang HY, Arbuthnot P, Kew M, Feitelson MA. Human S15a expression is upregulated by hepatitis B virus X protein. Mol Carcinog. 2004 May; 40(1):34-46. PMID: 15108328.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    98. Capovilla A, Arbuthnot P. Hepatitis B virus X protein does not influence essential steps of nucleotide excision repair effected by human liver extracts. Biochem Biophys Res Commun. 2003 Dec 19; 312(3):806-10. PMID: 14680837.
      Citations: 2     Fields:    Translation:HumansCells
    99. Lian Z, Liu J, Li L, Li X, Tufan NL, Clayton M, Wu MC, Wang HY, Arbuthnot P, Kew M, Feitelson MA. Upregulated expression of a unique gene by hepatitis B x antigen promotes hepatocellular growth and tumorigenesis. Neoplasia. 2003 May-Jun; 5(3):229-44. PMID: 12869306; PMCID: PMC1502406.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    100. Moolla N, Kew M, Arbuthnot P. Regulatory elements of hepatitis B virus transcription. J Viral Hepat. 2002 Sep; 9(5):323-31. PMID: 12225325.
      Citations: 71     Fields:    Translation:Cells
    101. Tufan NL, Lian Z, Liu J, Pan J, Arbuthnot P, Kew M, Clayton MM, Zhu M, Feitelson MA. Hepatitis Bx antigen stimulates expression of a novel cellular gene, URG4, that promotes hepatocellular growth and survival. Neoplasia. 2002 Jul-Aug; 4(4):355-68. PMID: 12082552; PMCID: PMC1531705.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    102. Zampieri L, Bianchi P, Ruff P, Arbuthnot P. Differential modulation by estradiol of P-glycoprotein drug resistance protein expression in cultured MCF7 and T47D breast cancer cells. Anticancer Res. 2002 Jul-Aug; 22(4):2253-9. PMID: 12174911.
      Citations: 14     Fields:    Translation:HumansCells
    103. Capovilla A, Arbuthnot P. Nucleotide excision repair by extracts of human fetal hepatocytes. FEBS Lett. 2002 May 08; 518(1-3):144-8. PMID: 11997035.
      Citations: 2     Fields:    Translation:HumansCells
    104. Lian Z, Liu J, Pan J, Satiroglu Tufan NL, Zhu M, Arbuthnot P, Kew M, Clayton MM, Feitelson MA. A cellular gene up-regulated by hepatitis B virus-encoded X antigen promotes hepatocellular growth and survival. Hepatology. 2001 Jul; 34(1):146-57. PMID: 11431746.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    105. Arbuthnot P, Kew M. Hepatitis B virus and hepatocellular carcinoma. Int J Exp Pathol. 2001 Apr; 82(2):77-100. PMID: 11454100; PMCID: PMC2517704.
      Citations: 93     Fields:    Translation:HumansAnimalsCells
    106. Weinberg M, Passman M, Kew M, Arbuthnot P. Hammerhead ribozyme-mediated inhibition of hepatitis B virus X gene expression in cultured cells. J Hepatol. 2000 Jul; 33(1):142-51. PMID: 10905598.
      Citations: 6     Fields:    Translation:HumansCells
    107. Arbuthnot P, Capovilla A, Kew M. Putative role of hepatitis B virus X protein in hepatocarcinogenesis: effects on apoptosis, DNA repair, mitogen-activated protein kinase and JAK/STAT pathways. J Gastroenterol Hepatol. 2000 Apr; 15(4):357-68. PMID: 10824878.
      Citations: 65     Fields:    Translation:HumansAnimalsCells
    108. Passman M, Weinberg M, Kew M, Arbuthnot P. In situ demonstration of inhibitory effects of hammerhead ribozymes that are targeted to the hepatitis Bx sequence in cultured cells. Biochem Biophys Res Commun. 2000 Feb 24; 268(3):728-33. PMID: 10679273.
      Citations: 12     Fields:    Translation:HumansCells
    109. Lian Z, Pan J, Liu J, Zhang S, Zhu M, Arbuthnot P, Kew M, Feitelson MA. The translation initiation factor, hu-Sui1 may be a target of hepatitis B X antigen in hepatocarcinogenesis. Oncogene. 1999 Mar 04; 18(9):1677-87. PMID: 10208429.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    110. Carmona S, Passman M, Kew M, Arbuthnot P. Site-directed mutagenesis by fusion of contiguous DNA fragments. Biotechniques. 1999 Mar; 26(3):382-4, 386. PMID: 10090968.
      Citations: 1     Fields:    Translation:HumansCells
    111. Carmona S, Prinz W, Arbuthnot P. Simplified ELISA for detecting antibodies to recombinant fusion proteins. Biotechniques. 1997 Oct; 23(4):627-30. PMID: 9343677.
      Citations:    Fields:    Translation:AnimalsPHPublic Health
    112. Capovilla A, Carmona S, Arbuthnot P. Hepatitis B virus X-protein binds damaged DNA and sensitizes liver cells to ultraviolet irradiation. Biochem Biophys Res Commun. 1997 Mar 06; 232(1):255-60. PMID: 9125143.
      Citations: 12     Fields:    Translation:Cells
    113. Arbuthnot PB, Bralet MP, Le Jossic C, Dedieu JF, Perricaudet M, Bréchot C, Ferry N. In vitro and in vivo hepatoma cell-specific expression of a gene transferred with an adenoviral vector. Hum Gene Ther. 1996 Aug 20; 7(13):1503-14. PMID: 8864751.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    114. Arbuthnot P, Bralet MP, Thomassin H, Danan JL, Bréchot C, Ferry N. Hepatoma cell-specific expression of a retrovirally transferred gene is achieved by alpha-fetoprotein but not insulinlike growth factor II regulatory sequences. Hepatology. 1995 Dec; 22(6):1788-96. PMID: 7489990.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    115. Grimm E, Arbuthnot P. Rapid purification of recombinant Taq DNA polymerase by freezing and high temperature thawing of bacterial expression cultures. Nucleic Acids Res. 1995 Nov 11; 23(21):4518-9. PMID: 7501478; PMCID: PMC307412.
      Citations: 7     Fields:    Translation:Cells
    116. Arbuthnot P, Fitschen W. Inhibition of primer extension by single mismatches during asymmetric re-amplification. Biochem J. 1992 Dec 15; 288 ( Pt 3):1073-4. PMID: 1471981; PMCID: PMC1131998.
      Citations: 1     Fields:    Translation:Cells
    117. Arbuthnot P, Kew M, Fitschen W. c-fos and c-myc oncoprotein expression in human hepatocellular carcinomas. Anticancer Res. 1991 Mar-Apr; 11(2):921-4. PMID: 1648336.
      Citations: 5     Fields:    Translation:Humans
    118. Arbuthnot P, Kew M, Parker I, Fitschen W. Expression of c-erbA in human hepatocellular carcinomas. Anticancer Res. 1989 Jul-Aug; 9(4):885-7. PMID: 2554788.
      Citations: 2     Fields:    Translation:HumansCells
    119. Arbuthnot PB, Cantrill RC. Purine nucleoside and nucleotide regulation of high affinity [3H]glutamate and [3H]aspartate uptake into rat brain synaptosomes. Int J Biochem. 1985; 17(6):753-5. PMID: 2863187.
      Citations:    Fields:    Translation:AnimalsCells
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