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Frederick

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Vuorio A, Budowle B, Raal F, Kovanen PT. Statins for the prevention of cardiovascular events associated with avian influenza: the COVID-19 pandemic as a reference. Ann Med. 2024 Dec; 56(1):2390166. PMID: 39152892; PMCID: PMC11332304.
      Citations:    Fields:    Translation:HumansAnimalsCellsPHPublic Health
    2. Mansfield BS, Mohamed F, Larouche M, Raal FJ. The Hurdle of Access to Emerging Therapies and Potential Solutions in the Management of Dyslipidemias. J Clin Med. 2024 Jul 16; 13(14). PMID: 39064199; PMCID: PMC11277596.
      Citations:    
    3. Gaudet D, Greber-Platzer S, Reeskamp LF, Iannuzzo G, Rosenson RS, Saheb S, Stefanutti C, Stroes E, Wiegman A, Turner T, Ali S, Banerjee P, Drewery T, McGinniss J, Waldron A, George RT, Zhao XQ, Pordy R, Zhao J, Bruckert E, Raal FJ. Evinacumab in homozygous familial hypercholesterolaemia: long-term safety and efficacy. Eur Heart J. 2024 Jul 12; 45(27):2422-2434. PMID: 38856678; PMCID: PMC11242450.
      Citations:    Fields:    Translation:HumansCTClinical Trials
    4. Wright RS, Ray KK, Landmesser U, Koenig W, Raal FJ, Leiter LA, Conde LG, Han J, Schwartz GG. Effects of Inclisiran in Patients With Atherosclerotic Cardiovascular Disease: A Pooled Analysis of the ORION-10 and ORION-11 Randomized Trials. Mayo Clin Proc. 2024 Jul 05. PMID: 39093262.
      Citations:    Fields:    
    5. Leiter LA, Raal FJ, Schwartz GG, Koenig W, Ray KK, Landmesser U, Han J, Conde LG, Wright RS. Inclisiran in individuals with diabetes or obesity: Post hoc pooled analyses of the ORION-9, ORION-10 and ORION-11 Phase 3 randomized trials. Diabetes Obes Metab. 2024 Aug; 26(8):3223-3237. PMID: 38757725.
      Citations:    Fields:    Translation:HumansCTClinical Trials
    6. Wright RS, Raal FJ, Koenig W, Landmesser U, Leiter LA, Vikarunnessa S, Lesogor A, Maheux P, Talloczy Z, Zang X, Schwartz GG, Ray KK. Inclisiran administration potently and durably lowers LDL-C over an extended-term follow-up: the ORION-8 trial. Cardiovasc Res. 2024 May 16. PMID: 38753448.
      Citations:    Fields:    
    7. Reijman MD, Tromp TR, Hutten BA, Hovingh GK, Blom DJ, Catapano AL, Cuchel M, Dann EJ, Gallo A, Hudgins LC, Raal FJ, Ray KK, Sadiq F, Soran H, Groothoff JW, Wiegman A, Kusters DM, Homozygous Familial Hypercholesterolaemia International Clinical Collaborators (HICC), Children with Homozygous Hypercholesterolemia on Lipoprotein Apheresis: an International Registry (C. Cardiovascular outcomes in patients with homozygous familial hypercholesterolaemia on lipoprotein apheresis initiated during childhood: long-term follow-up of an international cohort from two registries. Lancet Child Adolesc Health. 2024 Jul; 8(7):491-499. PMID: 38759658.
      Citations:    Fields:    Translation:Humans
    8. Klug EQ, Raal FJ. Heart groups in South Africa advocate for tighter LDL-C control and lipoprotein(a) testing to curb atherosclerotic cardiovascular disease. S Afr Med J. 2024 May 09; 114(5):e1973. PMID: 39041476.
      Citations:    Fields:    Translation:Humans
    9. Gu J, Gupta RN, Cheng H, Xu Y, Raal FJ. Current treatments for the management of homozygous familial hypercholesterolemia: a systematic review and commentary. Eur J Prev Cardiol. 2024 Apr 18. PMID: 38640433.
      Citations:    Fields:    
    10. Mulder JWCM, Tromp TR, Al-Khnifsawi M, Blom DJ, Chlebus K, Cuchel M, D'Erasmo L, Gallo A, Hovingh GK, Kim NT, Long J, Raal FJ, Schonck WAM, Soran H, Truong TH, Boersma E, Roeters van Lennep JE, Homozygous Familial Hypercholesterolemia International Clinical Collaborators. Sex Differences in Diagnosis, Treatment, and Cardiovascular Outcomes in Homozygous Familial Hypercholesterolemia. JAMA Cardiol. 2024 Apr 01; 9(4):313-322. PMID: 38353972; PMCID: PMC10867777.
      Citations: 1     Fields:    Translation:Humans
    11. Raal FJ, Hegele RA, Ruzza A, L?pez JAG, Bhatia AK, Wu J, Wang H, Gaudet D, Wiegman A, Wang J, Santos RD. Evolocumab Treatment in Pediatric Patients With Homozygous Familial Hypercholesterolemia: Pooled Data From Three Open-Label Studies. Arterioscler Thromb Vasc Biol. 2024 May; 44(5):1156-1164. PMID: 38545781; PMCID: PMC11042515.
      Citations:    Fields:    Translation:Humans
    12. Marais AD, Blom DJ, Raal FJ. Management of hyperlipidaemia. S Afr Med J. 2024 Mar 18; 114(3):e1016. PMID: 38525564.
      Citations:    Fields:    Translation:Humans
    13. Ray KK, Gunn LH, Conde LG, Raal FJ, Wright RS, Gosselin NH, Leiter LA, Koenig W, Schwartz GG, Landmesser U, ORION investigators. Estimating potential cardiovascular health benefits of improved population level control of LDL cholesterol through a twice-yearly siRNA-based approach: A simulation study of a health-system level intervention. Atherosclerosis. 2024 Apr; 391:117472. PMID: 38447434.
      Citations:    Fields:    Translation:Humans
    14. Santos RD, Ruzza A, Wang B, Maruff P, Schembri A, Bhatia AK, Mach F, Bergeron J, Gaudet I, St Pierre J, Kastelein JJP, Hovingh GK, Wiegman A, Gaudet D, Raal FJ. Evolocumab in paediatric heterozygous familial hypercholesterolaemia: cognitive function during 80 weeks of open-label extension treatment. Eur J Prev Cardiol. 2024 Feb 15; 31(3):302-310. PMID: 37855448.
      Citations:    Fields:    Translation:Humans
    15. Kileel EM, Zheng A, Bor J, Fox MP, Crowther NJ, George JA, Khoza S, Rosen S, Venter WDF, Raal F, Hibberd P, Brennan AT. Does Engagement in HIV Care Affect Screening, Diagnosis, and Control of Noncommunicable Diseases in Sub-Saharan Africa? A Systematic Review and Meta-analysis. AIDS Behav. 2024 Feb; 28(2):591-608. PMID: 38300475; PMCID: PMC10876721.
      Citations:    Fields:    Translation:HumansPHPublic Health
    16. Mohamed F, Raal FJ. Unraveling the Whipple Triad: Non-Islet Cell Tumor-Induced Hypoglycemia. JCEM Case Rep. 2024 Feb; 2(2):luae006. PMID: 38283730; PMCID: PMC10821760.
      Citations: 1     
    17. Brennan AT, Lauren E, Bor J, George JA, Chetty K, Mlisana K, Dai A, Khoza S, Rosen S, Stokes AC, Raal F, Hibberd P, Alexanian SM, Fox MP, Crowther NJ. Gaps in the type 2 diabetes care cascade: a national perspective using South Africa's National Health Laboratory Service (NHLS) database. BMC Health Serv Res. 2023 Dec 21; 23(1):1452. PMID: 38129852; PMCID: PMC10740239.
      Citations:    Fields:    Translation:HumansCTClinical Trials
    18. Wright RS, Koenig W, Landmesser U, Leiter LA, Raal FJ, Schwartz GG, Lesogor A, Maheux P, Stratz C, Zang X, Ray KK. Safety and Tolerability of Inclisiran for?Treatment of Hypercholesterolemia in?7 Clinical Trials. J Am Coll Cardiol. 2023 12 12; 82(24):2251-2261. PMID: 38057066.
      Citations: 3     Fields:    Translation:Humans
    19. Vuorio A, Kovanen PT, Raal FJ. Coronary microcirculatory dysfunction in hypercholesterolemic patients with COVID-19: potential benefit from cholesterol-lowering treatment. Ann Med. 2023 12; 55(1):2199218. PMID: 37068045; PMCID: PMC10116911.
      Citations: 2     Fields:    Translation:HumansCells
    20. Gu J, Kuznik A, Quon P, Chauhan A, Sravya TS, Raal FJ. Modelling the potential long-term survival benefit of evinacumab treatment vs. standard of care in patients with homozygous familial hypercholesterolaemia. Eur J Prev Cardiol. 2023 11 30; 30(17):1874-1880. PMID: 37314419.
      Citations:    Fields:    Translation:Humans
    21. Essop MR, Seedat F, Raal FJ. Dyslipidaemia in patients with chronic kidney disease - a neglected cardiovascular risk factor. S Afr Med J. 2023 Nov 06; 113(11):35-40. PMID: 38525632.
      Citations: 1     Fields:    Translation:Humans
    22. Raal F, Fourie N, Scott R, Blom D, De Vries Basson M, Kayikcioglu M, Caldwell K, Kallend D, Stein E, LIBerate-HeFH Investigators . Long-term efficacy and safety of lerodalcibep in heterozygous familial hypercholesterolaemia: the LIBerate-HeFH trial. Eur Heart J. 2023 Oct 21; 44(40):4272-4280. PMID: 37639462; PMCID: PMC10590131.
      Citations: 7     Fields:    
    23. Raal F, Durst R, Bi R, Talloczy Z, Maheux P, Lesogor A, Kastelein JJP, ORION-5 Study Investigators. Efficacy, Safety, and Tolerability of Inclisiran in Patients With Homozygous Familial Hypercholesterolemia: Results From the ORION-5 Randomized Clinical Trial. Circulation. 2024 01 30; 149(5):354-362. PMID: 37850379; PMCID: PMC10815002.
      Citations: 5     Fields:    Translation:Humans
    24. Landmesser U, Koenig W, Leiter LA, Raal FJ, Ray KK, Wright RS, Han J, Conde LG, Schwartz GG. Inclisiran in patients with prior myocardial infarction: A post hoc pooled analysis of the ORION-10 and ORION-11 Phase 3 randomised trials. Atherosclerosis. 2023 12; 386:117354. PMID: 38016401.
      Citations:    Fields:    Translation:HumansCTClinical Trials
    25. Raal FJ, Rosenson RS, Reeskamp LF, Kastelein JJP, Rubba P, Duell PB, Koseki M, Stroes E, Ali S, Banerjee P, Chan KC, Khilla N, McGinniss J, Pordy R, Zhang Y, Gaudet D. The Long-Term Efficacy and Safety of?Evinacumab in Patients With?Homozygous Familial Hypercholesterolemia. JACC Adv. 2023 Nov; 2(9):100648. PMID: 38938723; PMCID: PMC11198175.
      Citations: 1     
    26. Vuorio A, Budowle B, Raal F, Kovanen PT. Wildfire smoke exposure and cardiovascular disease-should statins be recommended to prevent cardiovascular events? Front Cardiovasc Med. 2023; 10:1259162. PMID: 37781301; PMCID: PMC10537918.
      Citations:    
    27. Mansfield BS, Raal FJ. Regression of cutaneous xanthomata in patient with homozygous familial hypercholesterolemia using novel therapies. Lancet. 2023 09 02; 402(10404):e11. PMID: 37659780.
      Citations:    Fields:    Translation:Humans
    28. Mansfield BS, Stevens B, Raal FJ, Mohamed F. Point-of-care testing compared to gold-standard laboratory methods in the measurement of serum lipids. Cardiovasc J Afr. 2023 Aug 31; 34:1-6. PMID: 37667971.
      Citations: 1     Fields:    
    29. Mohamed F, Mansfield B, Raal FJ. Targeting PCSK9 and Beyond for the Management of Low-Density Lipoprotein Cholesterol. J Clin Med. 2023 Aug 02; 12(15). PMID: 37568484; PMCID: PMC10419884.
      Citations: 3     
    30. Kalra DK, Vorla M, Michos ED, Agarwala A, Virani S, Duell PB, Raal FJ. Dyslipidemia in Human Immunodeficiency Virus Disease: JACC Review Topic of the Week. J Am Coll Cardiol. 2023 07 11; 82(2):171-181. PMID: 37407116.
      Citations: 1     Fields:    Translation:HumansCells
    31. Cuchel M, Raal FJ, Hegele RA, Al-Rasadi K, Arca M, Averna M, Bruckert E, Freiberger T, Gaudet D, Harada-Shiba M, Hudgins LC, Kayikcioglu M, Masana L, Parhofer KG, Roeters van Lennep JE, Santos RD, Stroes ESG, Watts GF, Wiegman A, Stock JK, Tokg?zoglu LS, Catapano AL, Ray KK. 2023 Update on European Atherosclerosis Society Consensus Statement on Homozygous Familial Hypercholesterolaemia: new treatments and clinical guidance. Eur Heart J. 2023 Jul 01; 44(25):2277-2291. PMID: 37130090; PMCID: PMC10314327.
      Citations: 30     Fields:    Translation:Humans
    32. Marais AD, Blom DJ, Raal FJ. Premature cardiovascular deaths. S Afr Med J. 2023 06 21; 113(7):6-7. PMID: 37882038.
      Citations:    Fields:    Translation:Humans
    33. Watts GF, Gidding SS, Hegele RA, Raal FJ, Sturm AC, Jones LK, Sarkies MN, Al-Rasadi K, Blom DJ, Daccord M, de Ferranti SD, Folco E, Libby P, Mata P, Nawawi HM, Ramaswami U, Ray KK, Stefanutti C, Yamashita S, Pang J, Thompson GR, Santos RD. International Atherosclerosis Society guidance for implementing best practice in the care of familial hypercholesterolaemia. Nat Rev Cardiol. 2023 12; 20(12):845-869. PMID: 37322181.
      Citations: 28     Fields:    Translation:Humans
    34. Kileel EM, Zheng A, Bor J, Fox MP, Crowther NJ, George JA, Khoza S, Rosen S, Venter WD, Raal F, Hibberd P, Brennan AT. Does engagement in HIV care affect screening, diagnosis, and control of noncommunicable diseases in sub-Saharan Africa? A systematic review and meta-analysis. medRxiv. 2023 Jun 08. PMID: 36778439; PMCID: PMC9915817.
      Citations:    
    35. Raal F, Cuchel M. Lipid metabolism. Curr Opin Lipidol. 2023 06 01; 34(3):93-95. PMID: 37098845.
      Citations:    Fields:    Translation:Humans
    36. Raal FJ. Homozygous Familial Hypercholesterolemia: The Future Looks?Brighter But Not for All. JACC Adv. 2023 May; 2(3):100324. PMID: 38939578; PMCID: PMC11198171.
      Citations:    
    37. Koenig W, Ray KK, Landmesser U, Leiter LA, Schwartz GG, Wright RS, Conde LG, Han J, Raal FJ. Efficacy and safety of inclisiran in patients with cerebrovascular disease: ORION-9, ORION-10, and ORION-11. Am J Prev Cardiol. 2023 Jun; 14:100503. PMID: 37252442; PMCID: PMC10209488.
      Citations: 3     
    38. Mohamed F, Raal FJ. Severe Hypophosphatemia: The Hidden Truth. Clin Chem. 2023 04 28; 69(5):450-453. PMID: 37115578.
      Citations:    Fields:    Translation:Humans
    39. Micklesfield LK, Munthali R, Agongo G, Asiki G, Boua P, Choma SS, Crowther NJ, Fabian J, G?mez-Oliv? FX, Kabudula C, Maimela E, Mohamed SF, Nonterah EA, Raal FJ, Sorgho H, Tluway FD, Wade AN, Norris SA, Ramsay M, as members of AWI-Gen and the H3Africa Consortium. Identifying the prevalence and correlates of multimorbidity in middle-aged men and women: a cross-sectional population-based study in four African countries. BMJ Open. 2023 03 14; 13(3):e067788. PMID: 36918238; PMCID: PMC10016250.
      Citations: 5     Fields:    Translation:Humans
    40. Vuorio A, Raal F, Kovanen PT. Familial hypercholesterolemia: The nexus of endothelial dysfunction and lipoprotein metabolism in COVID-19. Curr Opin Lipidol. 2023 06 01; 34(3):119-125. PMID: 36924390.
      Citations: 3     Fields:    Translation:HumansCells
    41. Khoury E, Lauzi?re A, Raal FJ, Mancini J, Gaudet D. Atherosclerotic plaque regression in homozygous familial hypercholesterolaemia: a case report of a long-term lipid-lowering therapy involving LDL-receptor-independent mechanisms. Eur Heart J Case Rep. 2023 Jan; 7(1):ytad029. PMID: 36727130; PMCID: PMC9883702.
      Citations: 3     
    42. Ray KK, Raal FJ, Kallend DG, Jaros MJ, Koenig W, Leiter LA, Landmesser U, Schwartz GG, Lawrence D, Friedman A, Garcia Conde L, Wright RS, ORION Phase III investigators. Inclisiran and cardiovascular events: a patient-level analysis of phase III trials. Eur Heart J. 2023 01 07; 44(2):129-138. PMID: 36331326; PMCID: PMC9825807.
      Citations: 43     Fields:    Translation:Humans
    43. Koenig W, Conde LG, Landmesser U, Leiter LA, Ray KK, Schwartz GG, Wright RS, Han J, Raal FJ. Efficacy and Safety of Inclisiran in Patients with Polyvascular Disease: Pooled, Post Hoc Analysis of the ORION-9, ORION-10, and ORION-11 Phase 3 Randomized Controlled Trials. Cardiovasc Drugs Ther. 2024 Jun; 38(3):493-503. PMID: 36550348; PMCID: PMC11101568.
      Citations: 10     Fields:    Translation:HumansCTClinical Trials
    44. Ray KK, Kallend D, Leiter LA, Raal FJ, Koenig W, Jaros MJ, Schwartz GG, Landmesser U, Garcia Conde L, Wright RS, ORION-11 Investigators. Effect of inclisiran on lipids in primary prevention: the ORION-11 trial. Eur Heart J. 2022 12 21; 43(48):5047-5057. PMID: 36331315; PMCID: PMC9769955.
      Citations: 23     Fields:    Translation:Humans
    45. Vuorio A, Kovanen PT, Raal F. Statin Needs to be Continued During Paxlovid Therapy in COVID-19. Clin Infect Dis. 2022 12 19; 75(12):2281-2282. PMID: 35975652; PMCID: PMC9494321.
      Citations: 3     Fields:    Translation:Humans
    46. Vuorio A, Raal F, Kovanen PT. Familial Hypercholesterolemia Patients with COVID-19-Effective Cholesterol-Lowering Therapy is Urgent both during and after Infection. Rev Cardiovasc Med. 2022 Dec; 23(12):410. PMID: 39076654; PMCID: PMC11270387.
      Citations:    Fields:    
    47. Agongo G, Raal F, Nonterah EA, Debpuur C, Oduro AR, Ramsay M, Crowther NJ. Non-HDL-C and LDL-C/HDL-C are associated with self-reported cardiovascular disease in a rural West African population: Analysis of an array of lipid metrics in an AWI-Gen sub-study. PLoS One. 2022; 17(12):e0278375. PMID: 36477684; PMCID: PMC9728928.
      Citations: 2     Fields:    Translation:Humans
    48. Vuorio A, Raal F, Kovanen PT. Drug-drug interaction with oral antivirals for the early treatment of COVID-19. Int J Infect Dis. 2023 02; 127:171-172. PMID: 36470504; PMCID: PMC9715460.
      Citations: 4     Fields:    Translation:Humans
    49. Mohamed F, Mansfield BS, Raal FJ. ANGPTL3 as a Drug Target in Hyperlipidemia and Atherosclerosis. Curr Atheroscler Rep. 2022 12; 24(12):959-967. PMID: 36367663; PMCID: PMC9650658.
      Citations: 12     Fields:    Translation:Humans
    50. Ruder S, Mansfield B, Immelman AR, Varki N, Miu P, Raal F, Tsimikas S. Lp(a), oxidized phospholipids and oxidation-specific epitopes are increased in subjects with keloid formation. Lipids Health Dis. 2022 Nov 01; 21(1):113. PMID: 36320028; PMCID: PMC9623907.
      Citations: 2     Fields:    Translation:HumansCells
    51. Hesse R, Raal FJ, Blom DJ, George JA. Familial Hypercholesterolemia Identification by Machine Learning Using Lipid Profile Data Performs as Well as Clinical Diagnostic Criteria. Circ Genom Precis Med. 2022 10; 15(5):e003324. PMID: 36154661.
      Citations: 5     Fields:    Translation:Humans
    52. Santos RD, Ruzza A, Hovingh GK, Stefanutti C, Mach F, Descamps OS, Bergeron J, Wang B, Bartuli A, Buonuomo PS, Greber-Platzer S, Luirink I, Bhatia AK, Raal FJ, Kastelein JJP, Wiegman A, Gaudet D. Paediatric patients with heterozygous familial hypercholesterolaemia treated with evolocumab for 80 weeks (HAUSER-OLE): a single-arm, multicentre, open-label extension of HAUSER-RCT. Lancet Diabetes Endocrinol. 2022 10; 10(10):732-740. PMID: 36075246.
      Citations: 10     Fields:    Translation:Humans
    53. Vuorio A, Raal F, Kovanen PT. Monkeypox is a global public health emergency: The role of repurposing cholesterol lowering drugs not to be forgotten. J Clin Lipidol. 2022 Sep-Oct; 16(5):757-758. PMID: 36153280; PMCID: PMC9528222.
      Citations:    Fields:    Translation:HumansPHPublic Health
    54. Vuorio A, Kovanen PT, Raal F. Cholesterol-lowering drugs for high-risk hypercholesterolemia patients with COVID-19 while on Paxlovid? therapy. Future Virol. 2022 Jul. PMID: 35935448; PMCID: PMC9345303.
      Citations: 8     
    55. Gaudet D, Ruzza A, Bridges I, Maruff P, Schembri A, Hamer A, Mach F, Bergeron J, Gaudet I, Pierre JS, Kastelein JJP, Hovingh GK, Wiegman A, Raal FJ, Santos RD. Cognitive function with evolocumab in pediatric heterozygous familial hypercholesterolemia. J Clin Lipidol. 2022 Sep-Oct; 16(5):676-684. PMID: 36210291.
      Citations: 1     Fields:    Translation:Humans
    56. Mansfield BS, Bhana S, Raal FJ. Dyslipidemia in South African patients with hypothyroidism. J Clin Transl Endocrinol. 2022 Sep; 29:100302. PMID: 35898802; PMCID: PMC9309410.
      Citations: 2     
    57. Schludi B, Giugliano RP, Sabatine MS, Raal FJ, Teramoto T, Koren MJ, Stein EA, Wang H, Monsalvo ML. Time-averaged low-density lipoprotein cholesterol lowering with evolocumab: Pooled analysis of phase 2 trials. J Clin Lipidol. 2022 Jul-Aug; 16(4):538-543. PMID: 35760720.
      Citations: 3     Fields:    Translation:HumansCTClinical Trials
    58. Raal F, Abelson M, Blignaut S, Burgess L, Coetzer S, Ebrahim I, Gibbon A, Jansen van Rensburg D, Jaros M, Lombard L, Van Nieuwenhuizen E, Pretorius M, Van Tonder A, Urbach D. Safety and efficacy of inclisiran in South African patients at high cardiovascular risk: A subanalysis of the ORION phase III clinical trials. S Afr Med J. 2022 05 31; 112(6):426-432. PMID: 36217872.
      Citations: 2     Fields:    Translation:HumansCTClinical Trials
    59. Vuorio A, Raal F, Ijäs P, Kaste M, Kovanen PT. Long-Term Cardiovascular and Cerebrovascular Challenges Posed by COVID-19 in Patients With Familial Hypercholesterolemia. Front Pharmacol. 2022; 13:890141. PMID: 35645833; PMCID: PMC9131188.
      Citations: 2     
    60. Blom DJ, Marais AD, Moodley R, van der Merwe N, van Tonder A, Raal FJ. RNA-based therapy in the management of lipid disorders: a review. Lipids Health Dis. 2022 Apr 23; 21(1):41. PMID: 35459248; PMCID: PMC9034497.
      Citations: 5     Fields:    Translation:Humans
    61. Raal FJ, Mohamed F. Statins: are they appropriate for all patients? Lancet Glob Health. 2022 03; 10(3):e305-e306. PMID: 35180403; PMCID: PMC8846614.
      Citations: 1     Fields:    Translation:Humans
    62. Vuorio A, Kovanen PT, Raal F. Opportunities for preventing further endothelial dysfunction in pregnant COVID-19 patients with familial hypercholesterolemia. J Clin Lipidol. 2022 Feb 12. PMID: 35232697; PMCID: PMC8837469.
      Citations: 2     Fields:    Translation:Humans
    63. Tromp TR, Hartgers ML, Hovingh GK, Vallejo-Vaz AJ, Ray KK, Soran H, Freiberger T, Bertolini S, Harada-Shiba M, Blom DJ, Raal FJ, Cuchel M, Homozygous Familial Hypercholesterolaemia International Clinical Collaborators. Worldwide experience of homozygous familial hypercholesterolaemia: retrospective cohort study. Lancet. 2022 02 19; 399(10326):719-728. PMID: 35101175.
      Citations: 40     Fields:    Translation:Humans
    64. Graham DF, Raal FJ. Management of familial hypercholesterolemia in pregnancy. Curr Opin Lipidol. 2021 12 01; 32(6):370-377. PMID: 34619689.
      Citations: 8     Fields:    Translation:Humans
    65. Siddiqui N, Deletic N, Raal F, Mohamed F. Acute Suppurative Thyroiditis Secondary to Escherichia coli Infection. Eur J Case Rep Intern Med. 2021; 8(11):003009. PMID: 34912744; PMCID: PMC8667994.
      Citations: 2     
    66. Vuorio A, Kovanen PT, Santos RD, Raal F. Prevention of Cardiovascular Burden in COVID-19 Patients Suffering from Familial Hypercholesterolemia: A Global Challenge. Cardiol Ther. 2022 Mar; 11(1):1-7. PMID: 34787816; PMCID: PMC8596860.
      Citations: 2     
    67. Bansal S, Ruzza A, Sawhney J, Kulkarni G, Iyengar S, Mehta V, Hamer A, Wu Y, Raal FJ. Evolocumab in patients with homozygous familial hypercholesterolemia in India. J Clin Lipidol. 2021 Nov-Dec; 15(6):814-821. PMID: 34750081.
      Citations: 3     Fields:    Translation:HumansCTClinical Trials
    68. Watts GF, Raal FJ, Chan DC. Transcriptomic therapy for dyslipidemias utilizing nucleic acids targeted at ANGPTL3. Future Cardiol. 2022 02; 18(2):143-153. PMID: 34651521.
      Citations: 8     Fields:    Translation:HumansCells
    69. Marais AD, Blom DJ, Raal FJ, The Lipid And Atherosclerosis Society Of Southern Africa OBOTLA. Familial hypercholesterolaemia in South Africa: A reminder. S Afr Med J. 2021 08 02; 111(8):700-701. PMID: 35227347.
      Citations:    Fields:    Translation:Humans
    70. Mohamed F, Botha TC, Raal FJ. Inhibition of angiopoietin-like 3 for the management of severe hypercholesterolemia. Curr Opin Lipidol. 2021 08 01; 32(4):213-218. PMID: 33883446.
      Citations: 9     Fields:    Translation:Humans
    71. Kovanen PT, Raal F, Vuorio A. Patients with familial hypercholesterolemia and COVID-19: Efficient and ongoing cholesterol lowering is paramount for the prevention of acute myocardial infarction. Am J Prev Cardiol. 2021 Sep; 7:100224. PMID: 34312613; PMCID: PMC8289723.
      Citations: 4     
    72. Seedat F, Patel M, Phillip V, Mohamed F, Marais AD, Blackhurst DM, Solomon G, Currin S, Raal FJ. Hyperlipidemic myeloma, a rare form of acquired dysbetalipoproteinemia, in an HIV seropositive African female. Clin Chim Acta. 2021 Sep; 520:71-75. PMID: 34052205.
      Citations: 1     Fields:    Translation:Humans
    73. Mohamed F, Raal FJ. Hyperpigmentation from Addison's Disease. N Engl J Med. 2021 May 06; 384(18):1752. PMID: 33951364.
      Citations: 1     Fields:    Translation:Humans
    74. Vuorio A, Raal F, Kovanen PT. Hospitalized Children With Familial Hypercholesterolemia and COVID-19: A Case for Preventive Anticoagulation. Front Cardiovasc Med. 2021; 8:657719. PMID: 33959645; PMCID: PMC8093379.
      Citations: 1     
    75. Brandts J, Dharmayat KI, Vallejo-Vaz AJ, Azar Sharabiani MT, Jones R, Kastelein JJP, Raal FJ, Ray KK. A meta-analysis of medications directed against PCSK9 in familial hypercholesterolemia. Atherosclerosis. 2021 05; 325:46-56. PMID: 33901739.
      Citations: 8     Fields:    Translation:Humans
    76. Stelten BML, Raal FJ, Marais AD, Riksen NP, Roeters van Lennep JE, Duell PB, van der Graaf M, Kluijtmans LAJ, Wevers RA, Verrips A. Cerebrotendinous xanthomatosis without neurological involvement. J Intern Med. 2021 11; 290(5):1039-1047. PMID: 33830582.
      Citations: 4     Fields:    Translation:Humans
    77. Mohamed F, Seedat F, Raal FJ. Novel therapies for familial hypercholesterolemia. Curr Opin Endocrinol Diabetes Obes. 2021 04 01; 28(2):188-195. PMID: 33278127.
      Citations: 2     Fields:    Translation:Humans
    78. Hayat M, Kerr R, Bentley AR, Rotimi CN, Raal FJ, Ramsay M. Correction: Genetic associations between serum low LDL-cholesterol levels and variants in LDLR, APOB, PCSK9 and LDLRAP1 in African populations. PLoS One. 2021; 16(3):e0249478. PMID: 33770136; PMCID: PMC7996995.
      Citations:    Fields:    
    79. Wright RS, Ray KK, Raal FJ, Kallend DG, Jaros M, Koenig W, Leiter LA, Landmesser U, Schwartz GG, Friedman A, Wijngaard PLJ, Garcia Conde L, Kastelein JJP, ORION Phase III Investigators. Pooled Patient-Level Analysis of Inclisiran Trials in Patients With Familial Hypercholesterolemia or Atherosclerosis. J Am Coll Cardiol. 2021 03 09; 77(9):1182-1193. PMID: 33663735.
      Citations: 59     Fields:    Translation:Humans
    80. Vuorio A, Raal F, Klingel R, Kovanen PT. Why continued lipoprotein apheresis is vital for homozygous familial hypercholesterolemia patients with COVID-19. J Clin Lipidol. 2021 Mar-Apr; 15(2):379-380. PMID: 34099192; PMCID: PMC8176771.
      Citations: 2     Fields:    Translation:HumansCellsPHPublic Health
    81. Raal FJ, Gaudet D, Gusarova V. Evinacumab for Homozygous Familial Hypercholesterolemia. Reply. N Engl J Med. 2021 02 11; 384(6):e17. PMID: 33567208.
      Citations: 1     Fields:    Translation:Humans
    82. Nonterah EA, Crowther NJ, Oduro A, Agongo G, Micklesfield LK, Boua PR, Choma SSR, Mohamed SF, Sorgho H, Tollman SM, Norris SA, Raal FJ, Grobbee DE, Ramsay M, Bots ML, Klipstein-Grobusch K, as part of the H3Africa AWI-Gen study. Poor cardiovascular health is associated with subclinical atherosclerosis in apparently healthy sub-Saharan African populations: an H3Africa AWI-Gen study. BMC Med. 2021 02 10; 19(1):30. PMID: 33563289; PMCID: PMC7874493.
      Citations: 11     Fields:    Translation:Humans
    83. Vuorio A, Raal F, Kaste M, Kovanen PT. Familial hypercholesterolaemia and COVID-19: A two-hit scenario for endothelial dysfunction amenable to treatment. Atherosclerosis. 2021 03; 320:53-60. PMID: 33540179; PMCID: PMC7830285.
      Citations: 18     Fields:    Translation:Humans
    84. Raal FJ, Mohamed F. Never too old to benefit from lipid-lowering treatment. Lancet. 2020 11 21; 396(10263):1608-1609. PMID: 33186536.
      Citations: 3     Fields:    Translation:HumansPHPublic Health
    85. Klug EQ, Raal FJ. New cholesterol targets for patients at high or very high cardiovascular risk and the indications for PCSK9 inhibitors. S Afr Med J. 2020 Oct 28; 110(11):13126. PMID: 33403972.
      Citations:    Fields:    Translation:Humans
    86. Raal FJ, Bahassi EM, Stevens B, Turner TA, Stein EA. Cascade Screening for Familial Hypercholesterolemia in South Africa: The Wits FIND-FH Program. Arterioscler Thromb Vasc Biol. 2020 11; 40(11):2747-2755. PMID: 32878475.
      Citations: 2     Fields:    Translation:Humans
    87. Blom DJ, Ranjith N, Joshi P, Naidoo P, van Tonder A, Musa MG, Joshi S, Leisegang R, Trokis JS, Makan H, Raal FJ. The therapeutic management of South African dyslipidaemic patients at very high cardiovascular risk (CARDIO TRACK): a cross-sectional study. Cardiovasc J Afr. 2020 Sep/Oct; 31(5):245-251. PMID: 33151240; PMCID: PMC8762769.
      Citations:    Fields:    Translation:HumansCells
    88. Raal FJ, Rosenson RS, Reeskamp LF, Hovingh GK, Kastelein JJP, Rubba P, Ali S, Banerjee P, Chan KC, Gipe DA, Khilla N, Pordy R, Weinreich DM, Yancopoulos GD, Zhang Y, Gaudet D, ELIPSE HoFH Investigators. Evinacumab for Homozygous Familial Hypercholesterolemia. N Engl J Med. 2020 08 20; 383(8):711-720. PMID: 32813947.
      Citations: 201     Fields:    Translation:HumansCTClinical Trials
    89. Seedat F, Raal F, Martinson N, Variava E. LIPID AND LIPOPROTEIN LEVELS IN HIV-INFECTED ADULTS WITH SEPSIS COMPARED TO HEALTHY HIV- INFECTED CONTROLS. Afr J Infect Dis. 2020; 14(2):1-9. PMID: 33884344; PMCID: PMC8047293.
      Citations: 1     
    90. Borén J, Chapman MJ, Krauss RM, Packard CJ, Bentzon JF, Binder CJ, Daemen MJ, Demer LL, Hegele RA, Nicholls SJ, Nordestgaard BG, Watts GF, Bruckert E, Fazio S, Ference BA, Graham I, Horton JD, Landmesser U, Laufs U, Masana L, Pasterkamp G, Raal FJ, Ray KK, Schunkert H, Taskinen MR, van de Sluis B, Wiklund O, Tokgozoglu L, Catapano AL, Ginsberg HN. Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel. Eur Heart J. 2020 06 21; 41(24):2313-2330. PMID: 32052833; PMCID: PMC7308544.
      Citations: 404     Fields:    Translation:Humans
    91. Hovingh GK, Lepor NE, Kallend D, Stoekenbroek RM, Wijngaard PLJ, Raal FJ. Inclisiran Durably Lowers Low-Density Lipoprotein Cholesterol and Proprotein Convertase Subtilisin/Kexin Type 9 Expression in Homozygous Familial Hypercholesterolemia: The ORION-2 Pilot Study. Circulation. 2020 06 02; 141(22):1829-1831. PMID: 32479195.
      Citations: 30     Fields:    Translation:Humans
    92. Hesse R, Seedat F, Raal FJ, Snyman T, George JA. Cryptogenic Cushing Syndrome Due to a White Lie. Clin Chem. 2020 05 01; 66(5):658-663. PMID: 32353140.
      Citations:    Fields:    Translation:Humans
    93. Pinchevsky Y, Butkow N, Raal FJ, Chirwa T, Rothberg A. Demographic and Clinical Factors Associated with Development of Type 2 Diabetes: A Review of the Literature. Int J Gen Med. 2020; 13:121-129. PMID: 32280262; PMCID: PMC7127847.
      Citations: 22     
    94. Ray KK, Wright RS, Kallend D, Koenig W, Leiter LA, Raal FJ, Bisch JA, Richardson T, Jaros M, Wijngaard PLJ, Kastelein JJP, ORION-10 and ORION-11 Investigators. Two Phase 3 Trials of Inclisiran in Patients with Elevated LDL Cholesterol. N Engl J Med. 2020 04 16; 382(16):1507-1519. PMID: 32187462.
      Citations: 330     Fields:    Translation:HumansCTClinical Trials
    95. Raal FJ, Kallend D, Ray KK, Turner T, Koenig W, Wright RS, Wijngaard PLJ, Curcio D, Jaros MJ, Leiter LA, Kastelein JJP, ORION-9 Investigators. Inclisiran for the Treatment of Heterozygous Familial Hypercholesterolemia. N Engl J Med. 2020 04 16; 382(16):1520-1530. PMID: 32197277.
      Citations: 219     Fields:    Translation:HumansCTClinical Trials
    96. Hayat M, Kerr R, Bentley AR, Rotimi CN, Raal FJ, Ramsay M. Genetic associations between serum low LDL-cholesterol levels and variants in LDLR, APOB, PCSK9 and LDLRAP1 in African populations. PLoS One. 2020; 15(2):e0229098. PMID: 32084179; PMCID: PMC7034850.
      Citations: 6     Fields:    Translation:Humans
    97. Santos RD, Stein EA, Hovingh GK, Blom DJ, Soran H, Watts GF, López JAG, Bray S, Kurtz CE, Hamer AW, Raal FJ. Long-Term Evolocumab in Patients With Familial Hypercholesterolemia. J Am Coll Cardiol. 2020 02 18; 75(6):565-574. PMID: 32057369.
      Citations: 57     Fields:    Translation:HumansCTClinical Trials
    98. Watts GF, Gidding SS, Mata P, Pang J, Sullivan DR, Yamashita S, Raal FJ, Santos RD, Ray KK. Familial hypercholesterolaemia: evolving knowledge for designing adaptive models of care. Nat Rev Cardiol. 2020 06; 17(6):360-377. PMID: 31974482.
      Citations: 27     Fields:    Translation:Humans
    99. Raal FJ, Chilton R, Ranjith N, Rambiritch V, Leisegang RF, Ebrahim IO, Tonder AV, Shunmoogam N, Bouharati C, Musa MG, Karamchand S, Naidoo P, Blom DJ. PCSK9 Inhibitors: From Nature's Lessons to Clinical Utility. Endocr Metab Immune Disord Drug Targets. 2020; 20(6):840-854. PMID: 32053090.
      Citations: 2     Fields:    Translation:HumansAnimals
    100. Mohamed F, Raal F. A pain in the neck. BMJ. 2019 Nov 21; 367:l6008. PMID: 31753833.
      Citations:    Fields:    Translation:Humans
    101. Blom DJ, Raal FJ, Santos RD, Marais AD. Lomitapide and Mipomersen-Inhibiting Microsomal Triglyceride Transfer Protein (MTP) and apoB100 Synthesis. Curr Atheroscler Rep. 2019 11 19; 21(12):48. PMID: 31741187.
      Citations: 21     Fields:    Translation:HumansCells
    102. Brennan AT, Berry KM, Rosen S, Stokes A, Crowther NJ, George J, Raal F, Cassim N, Sanne I, Long L, Fox MP. Growth curve modelling to determine distinct BMI trajectory groups in HIV-positive adults on antiretroviral therapy in South Africa. AIDS. 2019 11 01; 33(13):2049-2059. PMID: 31577571; PMCID: PMC6939155.
      Citations: 7     Fields:    Translation:Humans
    103. Koren MJ, Sabatine MS, Giugliano RP, Langslet G, Wiviott SD, Ruzza A, Ma Y, Hamer AW, Wasserman SM, Raal FJ. Long-Term Efficacy and Safety of Evolocumab in Patients With Hypercholesterolemia. J Am Coll Cardiol. 2019 10 29; 74(17):2132-2146. PMID: 31648705.
      Citations: 46     Fields:    Translation:Humans
    104. Hegele RA, Borén J, Ginsberg HN, Arca M, Averna M, Binder CJ, Calabresi L, Chapman MJ, Cuchel M, von Eckardstein A, Frikke-Schmidt R, Gaudet D, Hovingh GK, Kronenberg F, Lütjohann D, Parhofer KG, Raal FJ, Ray KK, Remaley AT, Stock JK, Stroes ES, Tokgözoglu L, Catapano AL. Rare dyslipidaemias, from phenotype to genotype to management: a European Atherosclerosis Society task force consensus statement. Lancet Diabetes Endocrinol. 2020 01; 8(1):50-67. PMID: 31582260.
      Citations: 39     Fields:    Translation:Humans
    105. Blom DJ, Breedt J, Burgess LJ, Ebrahim IO, Ellis G, Soma P, van der Walt E, Naidoo P, van Tonder A, Raal FJ. Long-term safety and efficacy of alirocumab in South African patients with heterozygous familial hypercholesterolaemia: the ODYSSEY Open-Label Extension study. Cardiovasc J Afr. 2019 Sep/Oct 23; 30(5):279-284. PMID: 31512717; PMCID: PMC8802375.
      Citations: 2     Fields:    Translation:HumansCellsCTClinical Trials
    106. Marais AD, Kotze MJ, Raal FJ, Khine AA, Talmud PJ, Humphries SE. Familial hypercholesterolaemia workshop for leveraging point-of-care testing and personalised medicine in association with the Lipid and Atherosclerosis Society of Southern Africa. Cardiovasc J Afr. 2019 Sep/Oct; 30(5):297-304. PMID: 31746944; PMCID: PMC8802372.
      Citations: 1     Fields:    Translation:Humans
    107. Raal FJ, Mohamed F. More aggressive lipid lowering in people with diabetes? Lancet Diabetes Endocrinol. 2019 08; 7(8):587-589. PMID: 31272929.
      Citations:    Fields:    Translation:Humans
    108. Raal FJ, Tuomilehto J, Sposito AC, Fonseca FA, Averna M, Farnier M, Santos RD, Ferdinand KC, Wright RS, Navarese EP, Lerch DM, Louie MJ, Lee LV, Letierce A, Robinson JG. Treatment effect of alirocumab according to age group, smoking status, and hypertension: Pooled analysis from 10 randomized ODYSSEY studies. J Clin Lipidol. 2019 Sep - Oct; 13(5):735-743. PMID: 31377052.
      Citations: 1     Fields:    Translation:Humans
    109. Hamoui O, Omar MI, Raal FJ, Rashed W, Kane A, Alami M, Abreu P, Mashhoud W, Alsheikh-Ali AA. Increases in statin eligibility to reduce cardiovascular risk according to the 2013 ACC/AHA cholesterol guidelines in the Africa Middle East region: a sub-analysis of the Africa Middle East Cardiovascular Epidemiological (ACE) study. BMC Cardiovasc Disord. 2019 03 15; 19(1):61. PMID: 30876390; PMCID: PMC6420771.
      Citations: 3     Fields:    Translation:Humans
    110. Ginsberg HN, Tuomilehto J, Hovingh GK, Cariou B, Santos RD, Brown AS, Sanganalmath SK, Koren A, Thompson D, Raal FJ. Impact of Age on the Efficacy and Safety of Alirocumab in Patients with Heterozygous Familial Hypercholesterolemia. Cardiovasc Drugs Ther. 2019 02; 33(1):69-76. PMID: 30734207; PMCID: PMC6433806.
      Citations: 5     Fields:    Translation:HumansCells
    111. Blom DJ, Raal F, Amod A, Naidoo P, Lai YE, ICLPS SA study group. Management of low-density lipoprotein cholesterol levels in South Africa: the International ChoLesterol management Practice Study (ICLPS). Cardiovasc J Afr. 2019 Jan/Feb 23; 30(1):15-23. PMID: 30720848.
      Citations: 4     Fields:    Translation:Humans
    112. Klug E, Raal FJ, Marais AD, Smuts CM, Schamroth C, Jankelow D, Blom DJ, Webb DA. South African dyslipidaemia guideline consensus statement: 2018 update A joint statement from the South African Heart Association (SA Heart) and the Lipid and Atherosclerosis Society of Southern Africa (LASSA). S Afr Med J. 2018 10 26; 108(11b):973-1000. PMID: 30421699.
      Citations: 27     Fields:    Translation:HumansPHPublic Health
    113. Stroes E, Robinson JG, Raal FJ, Dufour R, Sullivan D, Kassahun H, Ma Y, Wasserman SM, Koren MJ. Consistent LDL-C response with evolocumab among patient subgroups in PROFICIO: A pooled analysis of 3146 patients from phase 3 studies. Clin Cardiol. 2018 Oct; 41(10):1328-1335. PMID: 30120772; PMCID: PMC6489970.
      Citations: 16     Fields:    Translation:HumansCTClinical Trials
    114. Pinchevsky Y, Raal F, Butkow N, Chirwa T, Distiller L, Rothberg A. Quality of care delivered to type 2 diabetes mellitus patients in public and private sector facilities in Johannesburg, South Africa. Int J Gen Med. 2018; 11:383-390. PMID: 30323645; PMCID: PMC6173174.
      Citations: 2     
    115. EAS Familial Hypercholesterolaemia Studies Collaboration, Vallejo-Vaz AJ, De Marco M, Stevens CAT, Akram A, Freiberger T, Hovingh GK, Kastelein JJP, Mata P, Raal FJ, Santos RD, Soran H, Watts GF, Abifadel M, Aguilar-Salinas CA, Al-Khnifsawi M, AlKindi FA, Alnouri F, Alonso R, Al-Rasadi K, Al-Sarraf A, Ashavaid TF, Binder CJ, Bogsrud MP, Bourbon M, Bruckert E, Chlebus K, Corral P, Descamps O, Durst R, Ezhov M, Fras Z, Genest J, Groselj U, Harada-Shiba M, Kayikcioglu M, Lalic K, Lam CSP, Latkovskis G, Laufs U, Liberopoulos E, Lin J, Maher V, Majano N, Marais AD, März W, Mirrakhimov E, Miserez AR, Mitchenko O, Nawawi HM, Nordestgaard BG, Paragh G, Petrulioniene Z, Pojskic B, Postadzhiyan A, Reda A, Reiner Ž, Sadoh WE, Sahebkar A, Shehab A, Shek AB, Stoll M, Su TC, Subramaniam T, Susekov AV, Symeonides P, Tilney M, Tomlinson B, Truong TH, Tselepis AD, Tybjærg-Hansen A, Vázquez-Cárdenas A, Viigimaa M, Vohnout B, Widén E, Yamashita S, Banach M, Gaita D, Jiang L, Nilsson L, Santos LE, Schunkert H, Tokgözoglu L, Car J, Catapano AL, Ray KK, EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC) Investigators. Overview of the current status of familial hypercholesterolaemia care in over 60 countries - The EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC). Atherosclerosis. 2018 10; 277:234-255. PMID: 30270054.
      Citations: 67     Fields:    Translation:Humans
    116. Raal FJ, Hovingh GK, Catapano AL. Familial hypercholesterolemia treatments: Guidelines and new therapies. Atherosclerosis. 2018 10; 277:483-492. PMID: 30270089.
      Citations: 60     Fields:    Translation:HumansCells
    117. Botha TC, Pilcher GJ, Wolmarans K, Blom DJ, Raal FJ. Statins and other lipid-lowering therapy and pregnancy outcomes in homozygous familial hypercholesterolaemia: A retrospective review of 39 pregnancies. Atherosclerosis. 2018 10; 277:502-507. PMID: 30270091.
      Citations: 14     Fields:    Translation:HumansCells
    118. Mach F, Ray KK, Wiklund O, Corsini A, Catapano AL, Bruckert E, De Backer G, Hegele RA, Hovingh GK, Jacobson TA, Krauss RM, Laufs U, Leiter LA, März W, Nordestgaard BG, Raal FJ, Roden M, Santos RD, Stein EA, Stroes ES, Thompson PD, Tokgözoglu L, Vladutiu GD, Gencer B, Stock JK, Ginsberg HN, Chapman MJ, European Atherosclerosis Society Consensus Panel. Adverse effects of statin therapy: perception vs. the evidence - focus on glucose homeostasis, cognitive, renal and hepatic function, haemorrhagic stroke and cataract. Eur Heart J. 2018 07 14; 39(27):2526-2539. PMID: 29718253; PMCID: PMC6047411.
      Citations: 110     Fields:    Translation:Humans
    119. Gaudet D, Langslet G, Gidding SS, Luirink IK, Ruzza A, Kurtz C, Lu C, Somaratne R, Raal FJ, Wiegman A. Efficacy, safety, and tolerability of evolocumab in pediatric patients with heterozygous familial hypercholesterolemia: Rationale and design of the HAUSER-RCT study. J Clin Lipidol. 2018 Sep - Oct; 12(5):1199-1207. PMID: 30318065.
      Citations: 7     Fields:    Translation:Humans
    120. Thompson GR, Blom DJ, Marais AD, Seed M, Pilcher GJ, Raal FJ. Survival in homozygous familial hypercholesterolaemia is determined by the on-treatment level of serum cholesterol. Eur Heart J. 2018 04 07; 39(14):1162-1168. PMID: 29106543.
      Citations: 31     Fields:    Translation:Humans
    121. Smyth N, Ramsay M, Raal FJ. Population specific genetic heterogeneity of familial hypercholesterolemia in South Africa. Curr Opin Lipidol. 2018 04; 29(2):72-79. PMID: 29369830.
      Citations: 2     Fields:    Translation:Humans
    122. Zamparini JM, Immelman AR, Raal FJ. Fibroblast growth factor-23 in patients with homozygous familial hypercholesterolemia. J Clin Lipidol. 2018 May - Jun; 12(3):767-772. PMID: 29550495.
      Citations: 2     Fields:    Translation:Humans
    123. Raal FJ, Alsheikh-Ali AA, Omar MI, Rashed W, Hamoui O, Kane A, Alami M, Abreu P, Mashhoud WM. Cardiovascular risk factor burden in Africa and the Middle East across country income categories: a post hoc analysis of the cross-sectional Africa Middle East Cardiovascular Epidemiological (ACE) study. Arch Public Health. 2018; 76:15. PMID: 29449941; PMCID: PMC5812200.
      Citations: 16     
    124. Thedrez A, Blom DJ, Ramin-Mangata S, Blanchard V, Croyal M, Chemello K, Nativel B, Pichelin M, Cariou B, Bourane S, Tang L, Farnier M, Raal FJ, Lambert G. Homozygous Familial Hypercholesterolemia Patients With Identical Mutations Variably Express the LDLR (Low-Density Lipoprotein Receptor): Implications for the Efficacy of Evolocumab. Arterioscler Thromb Vasc Biol. 2018 03; 38(3):592-598. PMID: 29284604; PMCID: PMC5823753.
      Citations: 32     Fields:    Translation:HumansCellsCTClinical Trials
    125. Pinchevsky Y, Butkow N, Chirwa T, Raal F. Treatment Gaps Found in the Management of Type 2 Diabetes at a Community Health Centre in Johannesburg, South Africa. J Diabetes Res. 2017; 2017:9536025. PMID: 29130053; PMCID: PMC5654246.
      Citations: 12     Fields:    Translation:Humans
    126. Hovingh GK, Raal FJ, Dent R, Stefanutti C, Descamps O, Masana L, Lira A, Bridges I, Coll B, Sullivan D. Long-term safety, tolerability, and efficacy of evolocumab in patients with heterozygous familial hypercholesterolemia. J Clin Lipidol. 2017 Nov - Dec; 11(6):1448-1457. PMID: 29066265.
      Citations: 14     Fields:    Translation:HumansCTClinical Trials
    127. Leipold R, Raal F, Ishak J, Hovingh K, Phillips H. The effect of lomitapide on cardiovascular outcome measures in homozygous familial hypercholesterolemia: A modelling analysis. Eur J Prev Cardiol. 2017 11; 24(17):1843-1850. PMID: 28925748.
      Citations: 10     Fields:    Translation:HumansCells
    128. Stein EA, Dann EJ, Wiegman A, Skovby F, Gaudet D, Sokal E, Charng MJ, Mohamed M, Luirink I, Raichlen JS, Sundén M, Carlsson SC, Raal FJ, Kastelein JJP. Efficacy of Rosuvastatin in Children With Homozygous Familial Hypercholesterolemia and Association With Underlying Genetic Mutations. J Am Coll Cardiol. 2017 Aug 29; 70(9):1162-1170. PMID: 28838366.
      Citations: 18     Fields:    Translation:Humans
    129. Ference BA, Ginsberg HN, Graham I, Ray KK, Packard CJ, Bruckert E, Hegele RA, Krauss RM, Raal FJ, Schunkert H, Watts GF, Borén J, Fazio S, Horton JD, Masana L, Nicholls SJ, Nordestgaard BG, van de Sluis B, Taskinen MR, Tokgözoglu L, Landmesser U, Laufs U, Wiklund O, Stock JK, Chapman MJ, Catapano AL. Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel. Eur Heart J. 2017 Aug 21; 38(32):2459-2472. PMID: 28444290; PMCID: PMC5837225.
      Citations: 1015     Fields:    
    130. Koren MJ, Sabatine MS, Giugliano RP, Langslet G, Wiviott SD, Kassahun H, Ruzza A, Ma Y, Somaratne R, Raal FJ. Long-term Low-Density Lipoprotein Cholesterol-Lowering Efficacy, Persistence, and Safety of Evolocumab in Treatment of Hypercholesterolemia: Results Up to 4 Years From the Open-Label OSLER-1 Extension Study. JAMA Cardiol. 2017 06 01; 2(6):598-607. PMID: 28291870; PMCID: PMC5815032.
      Citations: 47     Fields:    Translation:Humans
    131. Raal FJ, Hovingh GK, Blom D, Santos RD, Harada-Shiba M, Bruckert E, Couture P, Soran H, Watts GF, Kurtz C, Honarpour N, Tang L, Kasichayanula S, Wasserman SM, Stein EA. Long-term treatment with evolocumab added to conventional drug therapy, with or without apheresis, in patients with homozygous familial hypercholesterolaemia: an interim subset analysis of the open-label TAUSSIG study. Lancet Diabetes Endocrinol. 2017 04; 5(4):280-290. PMID: 28215937.
      Citations: 66     Fields:    Translation:HumansCTClinical Trials
    132. Ibe UK, Whittall R, Humphries SE, Pilcher G, Raal F. Analysis of mutations causing familial hypercholesterolaemia in black South African patients of different ancestr. S Afr Med J. 2017 Jan 30; 107(2):145-148. PMID: 28220743.
      Citations: 2     Fields:    
    133. EAS Familial Hypercholesterolaemia Studies Collaboration, Vallejo-Vaz AJ, Akram A, Kondapally Seshasai SR, Cole D, Watts GF, Hovingh GK, Kastelein JJ, Mata P, Raal FJ, Santos RD, Soran H, Freiberger T, Abifadel M, Aguilar-Salinas CA, Alnouri F, Alonso R, Al-Rasadi K, Banach M, Bogsrud MP, Bourbon M, Bruckert E, Car J, Ceska R, Corral P, Descamps O, Dieplinger H, Do CT, Durst R, Ezhov MV, Fras Z, Gaita D, Gaspar IM, Genest J, Harada-Shiba M, Jiang L, Kayikcioglu M, Lam CS, Latkovskis G, Laufs U, Liberopoulos E, Lin J, Lin N, Maher V, Majano N, Marais AD, März W, Mirrakhimov E, Miserez AR, Mitchenko O, Nawawi H, Nilsson L, Nordestgaard BG, Paragh G, Petrulioniene Z, Pojskic B, Reiner Ž, Sahebkar A, Santos LE, Schunkert H, Shehab A, Slimane MN, Stoll M, Su TC, Susekov A, Tilney M, Tomlinson B, Tselepis AD, Vohnout B, Widén E, Yamashita S, Catapano AL, Ray KK. Pooling and expanding registries of familial hypercholesterolaemia to assess gaps in care and improve disease management and outcomes: Rationale and design of the global EAS Familial Hypercholesterolaemia Studies Collaboration. Atheroscler Suppl. 2016 Dec; 22:1-32. PMID: 27939304.
      Citations: 24     Fields:    Translation:Humans
    134. Pinchevsky Y, Shukla VJ, Butkow N, Chirwa T, Raal F. Multi-ethnic differences in HbA1c, blood pressure, and low-density-lipid cholesterol control among South Africans living with type 2 diabetes, after a 4-year follow-up. Int J Gen Med. 2016; 9:419-426. PMID: 27895508; PMCID: PMC5117891.
      Citations: 5     
    135. Ginsberg HN, Rader DJ, Raal FJ, Guyton JR, Baccara-Dinet MT, Lorenzato C, Pordy R, Stroes E. Efficacy and Safety of Alirocumab in Patients with Heterozygous Familial Hypercholesterolemia and LDL-C of 160 mg/dl or Higher. Cardiovasc Drugs Ther. 2016 Oct; 30(5):473-483. PMID: 27618825; PMCID: PMC5055560.
      Citations: 76     Fields:    Translation:HumansCTClinical Trials
    136. Gaudet D, Watts GF, Robinson JG, Minini P, Sasiela WJ, Edelberg J, Louie MJ, Raal FJ. Effect of Alirocumab on Lipoprotein(a) Over =1.5 Years (from the Phase 3 ODYSSEY Program). Am J Cardiol. 2017 Jan 01; 119(1):40-46. PMID: 27793396.
      Citations: 38     Fields:    Translation:HumansCTClinical Trials
    137. Daya R, Bayat Z, Raal FJ. Effects of diabetes mellitus on health-related quality of life at a tertiary hospital in South Africa: A cross-sectional study. S Afr Med J. 2016 Aug 05; 106(9):918-28. PMID: 27601120.
      Citations: 8     Fields:    
    138. Santos RD, Gidding SS, Hegele RA, Cuchel MA, Barter PJ, Watts GF, Baum SJ, Catapano AL, Chapman MJ, Defesche JC, Folco E, Freiberger T, Genest J, Hovingh GK, Harada-Shiba M, Humphries SE, Jackson AS, Mata P, Moriarty PM, Raal FJ, Al-Rasadi K, Ray KK, Reiner Z, Sijbrands EJ, Yamashita S, International Atherosclerosis Society Severe Familial Hypercholesterolemia Panel. Defining severe familial hypercholesterolaemia and the implications for clinical management: a consensus statement from the International Atherosclerosis Society Severe Familial Hypercholesterolemia Panel. Lancet Diabetes Endocrinol. 2016 10; 4(10):850-61. PMID: 27246162.
      Citations: 129     Fields:    Translation:Humans
    139. Raal FJ, Stein EA. The Effects of Mipomersen on Inhibiting Hepatic VLDL Apolipoprotein B100 Synthesis and Propensity for Hepatic Steatosis. Clin Chem. 2016 08; 62(8):1052-3. PMID: 27225832.
      Citations:    Fields:    Translation:Humans
    140. Raal FJ, Giugliano RP, Sabatine MS, Koren MJ, Blom D, Seidah NG, Honarpour N, Lira A, Xue A, Chiruvolu P, Jackson S, Di M, Peach M, Somaratne R, Wasserman SM, Scott R, Stein EA. PCSK9 inhibition-mediated reduction in Lp(a) with evolocumab: an analysis of 10 clinical trials and the LDL receptor's role. J Lipid Res. 2016 06; 57(6):1086-96. PMID: 27102113; PMCID: PMC4878192.
      Citations: 64     Fields:    Translation:HumansCells
    141. Thedrez A, Sjouke B, Passard M, Prampart-Fauvet S, Guédon A, Croyal M, Dallinga-Thie G, Peter J, Blom D, Ciccarese M, Cefalù AB, Pisciotta L, Santos RD, Averna M, Raal F, Pintus P, Cossu M, Hovingh K, Lambert G. Proprotein Convertase Subtilisin Kexin Type 9 Inhibition for Autosomal Recessive Hypercholesterolemia-Brief Report. Arterioscler Thromb Vasc Biol. 2016 08; 36(8):1647-50. PMID: 27079874.
      Citations: 4     Fields:    Translation:HumansCells
    142. Raal FJ, Sjouke B, Hovingh GK, Isaac BF. Retrospective analysis of cohort database: Phenotypic variability in a large dataset of patients confirmed to have homozygous familial hypercholesterolemia. Data Brief. 2016 Jun; 7:1458-62. PMID: 27182539; PMCID: PMC4857223.
      Citations:    
    143. Raal FJ, Braamskamp MJ, Selvey SL, Sensinger CH, Kastelein JJ. Pediatric experience with mipomersen as adjunctive therapy for homozygous familial hypercholesterolemia. J Clin Lipidol. 2016 Jul-Aug; 10(4):860-869. PMID: 27578117.
      Citations: 13     Fields:    Translation:Humans
    144. Raal FJ, Sjouke B, Hovingh GK, Isaac BF. Phenotype diversity among patients with homozygous familial hypercholesterolemia: A cohort study. Atherosclerosis. 2016 May; 248:238-44. PMID: 27017151.
      Citations: 16     Fields:    Translation:HumansCTClinical Trials
    145. Sattar N, Preiss D, Robinson JG, Djedjos CS, Elliott M, Somaratne R, Wasserman SM, Raal FJ. Lipid-lowering efficacy of the PCSK9 inhibitor evolocumab (AMG 145) in patients with type 2 diabetes: a meta-analysis of individual patient data. Lancet Diabetes Endocrinol. 2016 05; 4(5):403-10. PMID: 26868195.
      Citations: 54     Fields:    Translation:Humans
    146. Stein EA, Raal F. Future Directions to Establish Lipoprotein(a) as a Treatment for Atherosclerotic Cardiovascular Disease. Cardiovasc Drugs Ther. 2016 Feb; 30(1):101-8. PMID: 26861250.
      Citations: 8     Fields:    Translation:Humans
    147. Chiang CE, Ferrières J, Gotcheva NN, Raal FJ, Shehab A, Sung J, Henriksson KM, Hermans MP. Suboptimal Control of Lipid Levels: Results from 29 Countries Participating in the Centralized Pan-Regional Surveys on the Undertreatment of Hypercholesterolaemia (CEPHEUS). J Atheroscler Thromb. 2016 May 02; 23(5):567-87. PMID: 26632163.
      Citations: 26     Fields:    Translation:Humans
    148. Stein EA, Raal FJ. Lipid-Lowering Drug Therapy for CVD Prevention: Looking into the Future. Curr Cardiol Rep. 2015 Nov; 17(11):104. PMID: 26385394.
      Citations: 13     Fields:    Translation:Humans
    149. Gidding SS, Champagne MA, de Ferranti SD, Defesche J, Ito MK, Knowles JW, McCrindle B, Raal F, Rader D, Santos RD, Lopes-Virella M, Watts GF, Wierzbicki AS, American Heart Association Atherosclerosis, Hypertension, and Obesity in Young Committee of Council . The Agenda for Familial Hypercholesterolemia: A Scientific Statement From the American Heart Association. Circulation. 2015 Dec 01; 132(22):2167-92. PMID: 26510694.
      Citations: 192     Fields:    Translation:Humans
    150. Vallejo-Vaz AJ, Kondapally Seshasai SR, Cole D, Hovingh GK, Kastelein JJ, Mata P, Raal FJ, Santos RD, Soran H, Watts GF, Abifadel M, Aguilar-Salinas CA, Akram A, Alnouri F, Alonso R, Al-Rasadi K, Banach M, Bogsrud MP, Bourbon M, Bruckert E, Car J, Corral P, Descamps O, Dieplinger H, Durst R, Freiberger T, Gaspar IM, Genest J, Harada-Shiba M, Jiang L, Kayikcioglu M, Lam CS, Latkovskis G, Laufs U, Liberopoulos E, Nilsson L, Nordestgaard BG, O'Donoghue JM, Sahebkar A, Schunkert H, Shehab A, Stoll M, Su TC, Susekov A, Widén E, Catapano AL, Ray KK. Familial hypercholesterolaemia: A global call to arms. Atherosclerosis. 2015 Nov; 243(1):257-9. PMID: 26408930.
      Citations: 54     Fields:    Translation:Humans
    151. Hegele RA, Gidding SS, Ginsberg HN, McPherson R, Raal FJ, Rader DJ, Robinson JG, Welty FK. Nonstatin Low-Density Lipoprotein-Lowering Therapy and Cardiovascular Risk Reduction-Statement From ATVB Council. Arterioscler Thromb Vasc Biol. 2015 Nov; 35(11):2269-80. PMID: 26376908; PMCID: PMC4758700.
      Citations: 16     Fields:    Translation:HumansCells
    152. Pinchevsky Y, Butkow N, Chirwa T, Raal FJ. Glycaemic, blood pressure and cholesterol control in 25 629 diabetics. Cardiovasc J Afr. 2015 Jul-Aug; 26(4):188-92. PMID: 26407221; PMCID: PMC4683285.
      Citations: 11     Fields:    Translation:Humans
    153. Wiegman A, Gidding SS, Watts GF, Chapman MJ, Ginsberg HN, Cuchel M, Ose L, Averna M, Boileau C, Borén J, Bruckert E, Catapano AL, Defesche JC, Descamps OS, Hegele RA, Hovingh GK, Humphries SE, Kovanen PT, Kuivenhoven JA, Masana L, Nordestgaard BG, Pajukanta P, Parhofer KG, Raal FJ, Ray KK, Santos RD, Stalenhoef AF, Steinhagen-Thiessen E, Stroes ES, Taskinen MR, Tybjærg-Hansen A, Wiklund O, European Atherosclerosis Society Consensus Panel. Familial hypercholesterolaemia in children and adolescents: gaining decades of life by optimizing detection and treatment. Eur Heart J. 2015 Sep 21; 36(36):2425-37. PMID: 26009596; PMCID: PMC4576143.
      Citations: 222     Fields:    Translation:Humans
    154. Robinson JG, Farnier M, Krempf M, Bergeron J, Luc G, Averna M, Stroes ES, Langslet G, Raal FJ, El Shahawy M, Koren MJ, Lepor NE, Lorenzato C, Pordy R, Chaudhari U, Kastelein JJ, ODYSSEY LONG TERM Investigators. Efficacy and safety of alirocumab in reducing lipids and cardiovascular events. N Engl J Med. 2015 Apr 16; 372(16):1489-99. PMID: 25773378.
      Citations: 668     Fields:    Translation:Humans
    155. Sabatine MS, Giugliano RP, Wiviott SD, Raal FJ, Blom DJ, Robinson J, Ballantyne CM, Somaratne R, Legg J, Wasserman SM, Scott R, Koren MJ, Stein EA, Open-Label Study of Long-Term Evaluation against LDL Cholesterol (OSLER) Investigators. Efficacy and safety of evolocumab in reducing lipids and cardiovascular events. N Engl J Med. 2015 Apr 16; 372(16):1500-9. PMID: 25773607.
      Citations: 499     Fields:    Translation:Humans
    156. Raal FJ, Blom DJ. Anacetrapib in familial hypercholesterolaemia: pros and cons. Lancet. 2015 May 30; 385(9983):2124-6. PMID: 25743172.
      Citations: 2     Fields:    Translation:Humans
    157. Cuchel M, Bruckert E, Ginsberg HN, Raal FJ, Santos RD, Hegele RA, Kuivenhoven JA, Nordestgaard BG, Descamps OS, Steinhagen-Thiessen E, Tybjaerg-Hansen A, Watts GF, Averna M, Boileau C, Borén J, Catapano AL, Defesche JC, Hovingh GK, Humphries SE, Kovanen PT, Masana L, Pajukanta P, Parhofer KG, Ray KK, Stalenhoef AF, Stroes E, Taskinen MR, Wiegman A, Wiklund O, Chapman MJ, Avrupa Ateroskleroz Dernegi Ailevi Hiperkolesterolemi Uzlasi Paneli. [Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society]. Turk Kardiyol Dern Ars. 2015 Mar; 43 Suppl 1:1-14. PMID: 27326442.
      Citations: 4     Fields:    Translation:Humans
    158. Stroes ES, Thompson PD, Corsini A, Vladutiu GD, Raal FJ, Ray KK, Roden M, Stein E, Tokgözoglu L, Nordestgaard BG, Bruckert E, De Backer G, Krauss RM, Laufs U, Santos RD, Hegele RA, Hovingh GK, Leiter LA, Mach F, März W, Newman CB, Wiklund O, Jacobson TA, Catapano AL, Chapman MJ, Ginsberg HN, European Atherosclerosis Society Consensus Panel. Statin-associated muscle symptoms: impact on statin therapy-European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management. Eur Heart J. 2015 May 01; 36(17):1012-22. PMID: 25694464; PMCID: PMC4416140.
      Citations: 366     Fields:    Translation:HumansCells
    159. Santos RD, Raal FJ, Catapano AL, Witztum JL, Steinhagen-Thiessen E, Tsimikas S. Mipomersen, an antisense oligonucleotide to apolipoprotein B-100, reduces lipoprotein(a) in various populations with hypercholesterolemia: results of 4 phase III trials. Arterioscler Thromb Vasc Biol. 2015 Mar; 35(3):689-99. PMID: 25614280; PMCID: PMC4344404.
      Citations: 65     Fields:    Translation:HumansCells
    160. Santos RD, Raal FJ, Donovan JM, Cromwell WC. Mipomersen preferentially reduces small low-density lipoprotein particle number in patients with hypercholesterolemia. J Clin Lipidol. 2015 Mar-Apr; 9(2):201-9. PMID: 25911076.
      Citations: 8     Fields:    Translation:HumansCTClinical Trials
    161. Stein EA, Raal FJ. New therapies for reducing low-density lipoprotein cholesterol. Endocrinol Metab Clin North Am. 2014 Dec; 43(4):1007-33. PMID: 25432394.
      Citations: 9     Fields:    Translation:Humans
    162. Raal FJ. The cardioprotective diet: carbohydrates versus fat. Cardiovasc J Afr. 2014 Nov-Dec; 25(6):302. PMID: 25629718.
      Citations:    Fields:    Translation:Humans
    163. Raal FJ, Stein EA, Dufour R, Turner T, Civeira F, Burgess L, Langslet G, Scott R, Olsson AG, Sullivan D, Hovingh GK, Cariou B, Gouni-Berthold I, Somaratne R, Bridges I, Scott R, Wasserman SM, Gaudet D, RUTHERFORD-2 Investigators. PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): a randomised, double-blind, placebo-controlled trial. Lancet. 2015 Jan 24; 385(9965):331-40. PMID: 25282519.
      Citations: 249     Fields:    Translation:HumansCTClinical Trials
    164. Raal FJ, Honarpour N, Blom DJ, Hovingh GK, Xu F, Scott R, Wasserman SM, Stein EA, TESLA Investigators. Inhibition of PCSK9 with evolocumab in homozygous familial hypercholesterolaemia (TESLA Part B): a randomised, double-blind, placebo-controlled trial. Lancet. 2015 Jan 24; 385(9965):341-50. PMID: 25282520.
      Citations: 219     Fields:    Translation:HumansCTClinical Trials
    165. Alsheikh-Ali AA, Omar MI, Raal FJ, Rashed W, Hamoui O, Kane A, Alami M, Abreu P, Mashhoud WM. Cardiovascular risk factor burden in Africa and the Middle East: the Africa Middle East Cardiovascular Epidemiological (ACE) study. PLoS One. 2014; 9(8):e102830. PMID: 25090638; PMCID: PMC4121128.
      Citations: 61     Fields:    Translation:Humans
    166. Cuchel M, Bruckert E, Ginsberg HN, Raal FJ, Santos RD, Hegele RA, Kuivenhoven JA, Nordestgaard BG, Descamps OS, Steinhagen-Thiessen E, Tybjærg-Hansen A, Watts GF, Averna M, Boileau C, Borén J, Catapano AL, Defesche JC, Hovingh GK, Humphries SE, Kovanen PT, Masana L, Pajukanta P, Parhofer KG, Ray KK, Stalenhoef AF, Stroes E, Taskinen MR, Wiegman A, Wiklund O, Chapman MJ, European Atherosclerosis Society Consensus Panel on Familial Hypercholesterolaemia. Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society. Eur Heart J. 2014 Aug 21; 35(32):2146-57. PMID: 25053660; PMCID: PMC4139706.
      Citations: 316     Fields:    Translation:Humans
    167. Lyons JG, Sliwa K, Carrington MJ, Raal F, Pretorius S, Thienemann F, Stewart S. Lower levels of high-density lipoprotein cholesterol in urban Africans presenting with communicable versus non-communicable forms of heart disease: the 'Heart of Soweto' hospital registry study. BMJ Open. 2014 Jul 14; 4(7):e005069. PMID: 25023131; PMCID: PMC4120399.
      Citations: 1     Fields:    Translation:Humans
    168. Watts GF, Gidding S, Wierzbicki AS, Toth PP, Alonso R, Brown WV, Bruckert E, Defesche J, Lin KK, Livingston M, Mata P, Parhofer KG, Raal FJ, Santos RD, Sijbrands EJ, Simpson WG, Sullivan DR, Susekov AV, Tomlinson B, Wiegman A, Yamashita S, Kastelein JJ, International Familial Hypercholesterolemia Foundation. Integrated guidance on the care of familial hypercholesterolaemia from the International FH Foundation. Eur J Prev Cardiol. 2015 Jul; 22(7):849-54. PMID: 24776375.
      Citations: 19     Fields:    Translation:Humans
    169. Raal FJ, Stein EA. What matters most in pediatric familial hypercholesterolemia, genotype or phenotype? J Lipid Res. 2014 May; 55(5):793-5. PMID: 24676341; PMCID: PMC3995455.
      Citations: 1     Fields:    Translation:Humans
    170. Stein EA, Giugliano RP, Koren MJ, Raal FJ, Roth EM, Weiss R, Sullivan D, Wasserman SM, Somaratne R, Kim JB, Yang J, Liu T, Albizem M, Scott R, Sabatine MS, PROFICIO Investigators. Efficacy and safety of evolocumab (AMG 145), a fully human monoclonal antibody to PCSK9, in hyperlipidaemic patients on various background lipid therapies: pooled analysis of 1359 patients in four phase 2 trials. Eur Heart J. 2014 Sep 01; 35(33):2249-59. PMID: 24598985.
      Citations: 46     Fields:    Translation:Humans
    171. Raal FJ, Giugliano RP, Sabatine MS, Koren MJ, Langslet G, Bays H, Blom D, Eriksson M, Dent R, Wasserman SM, Huang F, Xue A, Albizem M, Scott R, Stein EA. Reduction in lipoprotein(a) with PCSK9 monoclonal antibody evolocumab (AMG 145): a pooled analysis of more than 1,300 patients in 4 phase II trials. J Am Coll Cardiol. 2014 Apr 08; 63(13):1278-1288. PMID: 24509273.
      Citations: 117     Fields:    Translation:HumansCTClinical Trials
    172. Watts GF, Gidding S, Wierzbicki AS, Toth PP, Alonso R, Brown WV, Bruckert E, Defesche J, Lin KK, Livingston M, Mata P, Parhofer KG, Raal FJ, Santos RD, Sijbrands EJ, Simpson WG, Sullivan DR, Susekov AV, Tomlinson B, Wiegman A, Yamashita S, Kastelein JJ. Integrated guidance on the care of familial hypercholesterolemia from the International FH Foundation. J Clin Lipidol. 2014 Mar-Apr; 8(2):148-72. PMID: 24636175.
      Citations: 28     Fields:    Translation:Humans
    173. Watts GF, Gidding S, Wierzbicki AS, Toth PP, Alonso R, Brown WV, Bruckert E, Defesche J, Lin KK, Livingston M, Mata P, Parhofer KG, Raal FJ, Santos RD, Sijbrands EJ, Simpson WG, Sullivan DR, Susekov AV, Tomlinson B, Wiegman A, Yamashita S, Kastelein JJ, International FH Foundation. Integrated guidance on the care of familial hypercholesterolaemia from the International FH Foundation: executive summary. J Atheroscler Thromb. 2014; 21(4):368-74. PMID: 24892180.
      Citations: 11     Fields:    
    174. Stein EA, Raal F. Reduction of low-density lipoprotein cholesterol by monoclonal antibody inhibition of PCSK9. Annu Rev Med. 2014; 65:417-31. PMID: 24422577.
      Citations: 26     Fields:    Translation:HumansAnimals
    175. Hegele RA, Ginsberg HN, Chapman MJ, Nordestgaard BG, Kuivenhoven JA, Averna M, Borén J, Bruckert E, Catapano AL, Descamps OS, Hovingh GK, Humphries SE, Kovanen PT, Masana L, Pajukanta P, Parhofer KG, Raal FJ, Ray KK, Santos RD, Stalenhoef AF, Stroes E, Taskinen MR, Tybjærg-Hansen A, Watts GF, Wiklund O, European Atherosclerosis Society Consensus Panel. The polygenic nature of hypertriglyceridaemia: implications for definition, diagnosis, and management. Lancet Diabetes Endocrinol. 2014 Aug; 2(8):655-66. PMID: 24731657; PMCID: PMC4201123.
      Citations: 164     Fields:    Translation:HumansAnimals
    176. Watts GF, Gidding S, Wierzbicki AS, Toth PP, Alonso R, Brown WV, Bruckert E, Defesche J, Lin KK, Livingston M, Mata P, Parhofer KG, Raal FJ, Santos RD, Sijbrands EJ, Simpson WG, Sullivan DR, Susekov AV, Tomlinson B, Wiegman A, Yamashita S, Kastelein JJ. Integrated guidance on the care of familial hypercholesterolaemia from the International FH Foundation. Int J Cardiol. 2014 Feb 15; 171(3):309-25. PMID: 24418289.
      Citations: 93     Fields:    Translation:Humans
    177. Koren MJ, Giugliano RP, Raal FJ, Sullivan D, Bolognese M, Langslet G, Civeira F, Somaratne R, Nelson P, Liu T, Scott R, Wasserman SM, Sabatine MS, OSLER Investigators. Efficacy and safety of longer-term administration of evolocumab (AMG 145) in patients with hypercholesterolemia: 52-week results from the Open-Label Study of Long-Term Evaluation Against LDL-C (OSLER) randomized trial. Circulation. 2014 Jan 14; 129(2):234-43. PMID: 24255061.
      Citations: 71     Fields:    Translation:Humans
    178. Stein EA, Raal FJ. Targeting LDL: is lower better and is it safe? Best Pract Res Clin Endocrinol Metab. 2014 Jun; 28(3):309-24. PMID: 24840261.
      Citations: 11     Fields:    Translation:Humans
    179. Stein EA, Honarpour N, Wasserman SM, Xu F, Scott R, Raal FJ. Effect of the proprotein convertase subtilisin/kexin 9 monoclonal antibody, AMG 145, in homozygous familial hypercholesterolemia. Circulation. 2013 Nov 05; 128(19):2113-20. PMID: 24014831.
      Citations: 109     Fields:    Translation:Humans
    180. Raal FJ, Blom DJ, Naidoo S, Bramlage P, Brudi P. Prevalence of dyslipidaemia in statin-treated patients in South Africa: results of the DYSlipidaemia International Study (DYSIS). Cardiovasc J Afr. 2013 Sep; 24(8):330-8. PMID: 24240385; PMCID: PMC3821092.
      Citations: 3     Fields:    Translation:Humans
    181. Menezes CN, Crowther NJ, Duarte R, Van Amsterdam D, Evans D, Dickens C, Dix-Peek T, Rassool M, Prinsloo A, Raal F, Sanne I. A randomized clinical trial comparing metabolic parameters after 48 weeks of standard- and low-dose stavudine therapy and tenofovir disoproxil fumarate therapy in HIV-infected South African patients. HIV Med. 2014 Jan; 15(1):3-12. PMID: 23980620.
      Citations: 8     Fields:    Translation:Humans
    182. Nordestgaard BG, Chapman MJ, Humphries SE, Ginsberg HN, Masana L, Descamps OS, Wiklund O, Hegele RA, Raal FJ, Defesche JC, Wiegman A, Santos RD, Watts GF, Parhofer KG, Hovingh GK, Kovanen PT, Boileau C, Averna M, Borén J, Bruckert E, Catapano AL, Kuivenhoven JA, Pajukanta P, Ray K, Stalenhoef AF, Stroes E, Taskinen MR, Tybjærg-Hansen A, European Atherosclerosis Society Consensus Panel. Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: consensus statement of the European Atherosclerosis Society. Eur Heart J. 2013 Dec; 34(45):3478-90a. PMID: 23956253; PMCID: PMC3844152.
      Citations: 775     Fields:    Translation:Humans
    183. Stein EA, Raal FJ. Insights into PCSK9, low-density lipoprotein receptor, and low-density lipoprotein cholesterol metabolism: of mice and man. Circulation. 2013 Jun 18; 127(24):2372-4. PMID: 23690464.
      Citations: 12     Fields:    Translation:HumansAnimals
    184. Raal F, Panz V, Immelman A, Pilcher G. Elevated PCSK9 levels in untreated patients with heterozygous or homozygous familial hypercholesterolemia and the response to high-dose statin therapy. J Am Heart Assoc. 2013 Apr 24; 2(2):e000028. PMID: 23537802; PMCID: PMC3647281.
      Citations: 39     Fields:    Translation:Humans
    185. Stein EA, Raal FJ. Polygenic familial hypercholesterolaemia: does it matter? Lancet. 2013 Apr 13; 381(9874):1255-7. PMID: 23433574.
      Citations: 7     Fields:    Translation:Humans
    186. Raal F, Scott R, Somaratne R, Bridges I, Li G, Wasserman SM, Stein EA. Low-density lipoprotein cholesterol-lowering effects of AMG 145, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease in patients with heterozygous familial hypercholesterolemia: the Reduction of LDL-C with PCSK9 Inhibition in Heterozygous Familial Hypercholesterolemia Disorder (RUTHERFORD) randomized trial. Circulation. 2012 Nov 13; 126(20):2408-17. PMID: 23129602.
      Citations: 143     Fields:    Translation:HumansCTClinical Trials
    187. Raal FJ. Lomitapide for homozygous familial hypercholesterolaemia. Lancet. 2013 Jan 05; 381(9860):7-8. PMID: 23122767.
      Citations: 9     Fields:    Translation:Humans
    188. Menezes CN, Duarte R, Dickens C, Dix-Peek T, Van Amsterdam D, John MA, Ive P, Maskew M, Macphail P, Fox MP, Raal F, Sanne I, Crowther NJ. The early effects of stavudine compared with tenofovir on adipocyte gene expression, mitochondrial DNA copy number and metabolic parameters in South African HIV-infected patients: a randomized trial. HIV Med. 2013 Apr; 14(4):217-25. PMID: 23036096.
      Citations: 2     Fields:    Translation:HumansCells
    189. Sliwa K, Lyons JG, Carrington MJ, Lecour S, Marais AD, Raal FJ, Stewart S. Different lipid profiles according to ethnicity in the Heart of Soweto study cohort of de novo presentations of heart disease. Cardiovasc J Afr. 2012 Aug; 23(7):389-95. PMID: 22914997; PMCID: PMC3721871.
      Citations: 18     Fields:    Translation:Humans
    190. Panz V, Immelman A, Paiker J, Pilcher G, Raal F. High-dose statin therapy does not induce insulin resistance in patients with familial hypercholesterolemia. Metab Syndr Relat Disord. 2012 Oct; 10(5):351-7. PMID: 22816732.
      Citations: 3     Fields:    Translation:Humans
    191. Raal FJ. The cardiovascular health of the nation - should we be advocating a low-carbohydrate, high-fat diet? S Afr Med J. 2012 Jun 20; 102(9):740. PMID: 22958693.
      Citations:    Fields:    Translation:Humans
    192. Raal FJ, Santos RD. Homozygous familial hypercholesterolemia: current perspectives on diagnosis and treatment. Atherosclerosis. 2012 Aug; 223(2):262-8. PMID: 22398274.
      Citations: 84     Fields:    Translation:Humans
    193. Amira OC, Naicker S, Manga P, Sliwa K, Mia A, Raal F, Crowther NJ, Immelman RA, Olorunju S. Adiponectin and atherosclerosis risk factors in African hemodialysis patients: a population at low risk for atherosclerotic cardiovascular disease. Hemodial Int. 2012 Jan; 16(1):59-68. PMID: 22099423.
      Citations: 5     Fields:    Translation:Humans
    194. Raal FJ, Pilcher GJ, Panz VR, van Deventer HE, Brice BC, Blom DJ, Marais AD. Reduction in mortality in subjects with homozygous familial hypercholesterolemia associated with advances in lipid-lowering therapy. Circulation. 2011 Nov 15; 124(20):2202-7. PMID: 21986285.
      Citations: 95     Fields:    Translation:Humans
    195. Menezes CN, Maskew M, Sanne I, Crowther NJ, Raal FJ. A longitudinal study of stavudine-associated toxicities in a large cohort of South African HIV infected subjects. BMC Infect Dis. 2011 Sep 17; 11:244. PMID: 21923929; PMCID: PMC3189398.
      Citations: 30     Fields:    Translation:Humans
    196. Raal F, Schamroth C, Blom D, Marx J, Rajput M, Haus M, Hussain R, Cassim F, Nortjé M, Vandehoven G, Temmerman AM. CEPHEUS SA: a South African survey on the undertreatment of hypercholesterolaemia. Cardiovasc J Afr. 2011 Sep-Oct; 22(5):234-40. PMID: 21922121; PMCID: PMC3721857.
      Citations: 9     Fields:    Translation:Humans
    197. Bihl G, Amod A, Ellis G, Moore R, Raal FJ, Gernholtz T, Schamroth C, Horak A. Meeting of the minds. Should pre-hypertension in type 2 diabetes be treated? Cardiovasc J Afr. 2010 May-Jun; 21(3 Suppl):S9-S13. PMID: 20532426.
      Citations:    Fields:    Translation:Humans
    198. Raal FJ, Santos RD, Blom DJ, Marais AD, Charng MJ, Cromwell WC, Lachmann RH, Gaudet D, Tan JL, Chasan-Taber S, Tribble DL, Flaim JD, Crooke ST. Mipomersen, an apolipoprotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: a randomised, double-blind, placebo-controlled trial. Lancet. 2010 Mar 20; 375(9719):998-1006. PMID: 20227758.
      Citations: 299     Fields:    Translation:Humans
    199. Ntyintyane L, Panz V, Raal F, Gill G. Comparison between surrogate indices of insulin sensitivity and resistance, and the hyperinsulinaemic euglycaemic glucose clamp in urban South African blacks with and without coronary artery disease. Diab Vasc Dis Res. 2010 Apr; 7(2):151-7. PMID: 20382779.
      Citations: 5     Fields:    Translation:HumansCTClinical Trials
    200. Stein EA, Marais AD, Szamosi T, Raal FJ, Schurr D, Urbina EM, Hopkins PN, Karki S, Xu J, Misir S, Melino M. Colesevelam hydrochloride: efficacy and safety in pediatric subjects with heterozygous familial hypercholesterolemia. J Pediatr. 2010 Feb; 156(2):231-6.e1-3. PMID: 19879596.
      Citations: 20     Fields:    Translation:Humans
    201. Holland Z, Ntyintyane L, Gill G, Raal F. Carotid intima-media thickness is a predictor of coronary artery disease in South African black patients. Cardiovasc J Afr. 2009 Jul-Aug; 20(4):237-9. PMID: 19701535; PMCID: PMC3721310.
      Citations: 6     Fields:    Translation:Humans
    202. Ntyintyane L, Panz V, Raal FJ, Gill G. Leptin, adiponectin, and high-sensitivity C-reactive protein in relation to the metabolic syndrome in urban South African blacks with and without coronary artery disease. Metab Syndr Relat Disord. 2009 Jun; 7(3):243-8. PMID: 19462476.
      Citations: 13     Fields:    Translation:Humans
    203. Raal FJ. Pathogenesis and management of the dyslipidemia of the metabolic syndrome. Metab Syndr Relat Disord. 2009 Apr; 7(2):83-8. PMID: 19400742.
      Citations: 15     Fields:    Translation:Humans
    204. Ntyintyane L, Panz V, Raal F, Gill G. Postprandial hyperglycemia in urban South African blacks with and without coronary artery disease. Metab Syndr Relat Disord. 2009 Feb; 7(1):23-9. PMID: 19025445.
      Citations:    Fields:    Translation:Humans
    205. Mosendane T, Mosendane T, Raal FJ. Shift work and its effects on the cardiovascular system. Cardiovasc J Afr. 2008 Jul-Aug; 19(4):210-5. PMID: 18776968; PMCID: PMC3971766.
      Citations: 23     Fields:    Translation:HumansCells
    206. Blom DJ, Raal FJ, Marais AD. Discovering familial hypercholesterolaemia. S Afr Med J. 2008 Apr; 98(4):232. PMID: 18642461.
      Citations:    Fields:    Translation:Humans
    207. Raal FJ. Questioning the importance of LDL cholesterol: don't throw the baby out with the bathwater! Cardiovasc J Afr. 2008 Mar-Apr; 19(2):63-4. PMID: 18516348; PMCID: PMC3975214.
      Citations:    Fields:    Translation:Humans
    208. Ramjeeth A, Butkow N, Raal FJ, Maholwana-Mokgatlhe M. The evaluation of low-density lipoprotein cholesterol goals achieved in patients with established cardiovascular disease and/or hyperlipidaemia receiving lipid-lowering therapy: the South African Not at Goal study (SA-NAG). Cardiovasc J Afr. 2008 Mar-Apr; 19(2):88-94. PMID: 18516354; PMCID: PMC3975218.
      Citations: 2     Fields:    Translation:Humans
    209. Ntyintyane LM, Panz VR, Raal FJ, Gill GV. Postprandial lipaemia, metabolic syndrome and LDL particle size in urbanised South African blacks with and without coronary artery disease. QJM. 2008 Feb; 101(2):111-9. PMID: 18194974.
      Citations: 7     Fields:    Translation:Humans
    210. Raal F, Schamroth C, Patel J, Becker P. A multicentre, open-label, observational local study to evaluate the low-density lipoprotein cholesterol-lowering effect of ezetimibe as prescribed in daily routine practice in the South African population. Cardiovasc J Afr. 2007 Sep-Oct; 18(5):325-9. PMID: 17985033; PMCID: PMC3975545.
      Citations: 1     Fields:    Translation:HumansCTClinical Trials
    211. Marais AD, Raal FJ, Stein EA, Rader DJ, Blasetto J, Palmer M, Wilpshaar W. A dose-titration and comparative study of rosuvastatin and atorvastatin in patients with homozygous familial hypercholesterolaemia. Atherosclerosis. 2008 Mar; 197(1):400-6. PMID: 17727860.
      Citations: 21     Fields:    Translation:Humans
    212. Abera AB, Marais AD, Raal FJ, Leisegang F, Jones S, George P, Henderson HE. Autosomal recessive hypercholesterolaemia: discrimination of ARH protein and LDLR function in the homozygous FH phenotype. Clin Chim Acta. 2007 Mar; 378(1-2):33-7. PMID: 17150201.
      Citations: 2     Fields:    Translation:Humans
    213. Ntyintyane LM, Panz VR, Raal FJ, Gill GV. Metabolic syndrome, undiagnosed diabetes mellitus and insulin resistance are highly prevalent in urbanised South African blacks with coronary artery disease. Cardiovasc J S Afr. 2006 Mar-Apr; 17(2):50-5. PMID: 16733596.
      Citations: 7     Fields:    Translation:Humans
    214. Panz VR, Raal FJ, Paiker J, Immelman R, Miles H. Performance of the CardioChek PA and Cholestech LDX point-of-care analysers compared to clinical diagnostic laboratory methods for the measurement of lipids. Cardiovasc J S Afr. 2005 Mar-Apr; 16(2):112-7. PMID: 15915279.
      Citations: 42     Fields:    Translation:Humans
    215. Raal FJ. A single-centre retrospective observational study to evaluate the change in total cholesterol and LDL cholesterol in hyperlipidaemic patients switched from atorvastatin to simvastatin. Cardiovasc J S Afr. 2004 May-Jun; 15(3):118-23. PMID: 15258621.
      Citations:    Fields:    Translation:Humans
    216. Raal FJ, Schamroth C, Klug E, Mills P. The South African Lipid Guidelines: is there a need for an update? Cardiovasc J S Afr. 2004 Mar-Apr; 15(2):53-4. PMID: 15148537.
      Citations:    Fields:    Translation:Humans
    217. Brown SL, Raal FJ, Panz VR, Stevens BA, Veller MG. High-dose atorvastatin therapy is required for significant improvement of endothelial function in heterozygous familial hypercholesterolaemic patients. Cardiovasc J S Afr. 2004 Mar-Apr; 15(2):70-5. PMID: 15148541.
      Citations: 4     Fields:    Translation:HumansCTClinical Trials
    218. Raal FJ, Marais AD, Klepack E, Lovalvo J, McLain R, Heinonen T. Avasimibe, an ACAT inhibitor, enhances the lipid lowering effect of atorvastatin in subjects with homozygous familial hypercholesterolemia. Atherosclerosis. 2003 Dec; 171(2):273-9. PMID: 14644397.
      Citations: 6     Fields:    Translation:HumansCTClinical Trials
    219. McNamara L, Panz VR, Raal FJ, Paiker J, Joffe BI, Gordeuk VR, MacPhail AP. Basal endocrine status in African dietary iron overload. Endocrine. 2003 Aug; 21(3):241-4. PMID: 14515008.
      Citations:    Fields:    Translation:Humans
    220. Vorster HH, Raal FJ, Ubbink JB, Marais AD, Rajput MC. Phytosterols--a new dietary aid for the treatment of hypercholesterolaemia. S Afr Med J. 2003 Aug; 93(8):581-2. PMID: 14531113.
      Citations: 1     Fields:    Translation:Humans
    221. Panz VR, Bonegio R, Raal FJ, Maher H, Hsu HC, Joffe BI. Diabetogenic effect of tacrolimus in South African patients undergoing kidney transplantation1. Transplantation. 2002 Feb 27; 73(4):587-90. PMID: 11889436.
      Citations: 1     Fields:    Translation:Humans
    222. Paiker JE, Raal FJ, Waisberg R, Buthelezi EP. Quantity versus quality of LDL cholesterol in patients with familial hypercholesterolemia--which is more important? Clin Chim Acta. 2001 Dec; 314(1-2):167-73. PMID: 11718692.
      Citations: 1     Fields:    Translation:HumansCellsCTClinical Trials
    223. Magré J, Delépine M, Khallouf E, Gedde-Dahl T, Van Maldergem L, Sobel E, Papp J, Meier M, Mégarbané A, Bachy A, Verloes A, d'Abronzo FH, Seemanova E, Assan R, Baudic N, Bourut C, Czernichow P, Huet F, Grigorescu F, de Kerdanet M, Lacombe D, Labrune P, Lanza M, Loret H, Matsuda F, Navarro J, Nivelon-Chevalier A, Polak M, Robert JJ, Tric P, Tubiana-Rufi N, Vigouroux C, Weissenbach J, Savasta S, Maassen JA, Trygstad O, Bogalho P, Freitas P, Medina JL, Bonnicci F, Joffe BI, Loyson G, Panz VR, Raal FJ, O'Rahilly S, Stephenson T, Kahn CR, Lathrop M, Capeau J, BSCL Working Group. Identification of the gene altered in Berardinelli-Seip congenital lipodystrophy on chromosome 11q13. Nat Genet. 2001 Aug; 28(4):365-70. PMID: 11479539.
      Citations: 250     Fields:    Translation:HumansCells
    224. Joffe BI, Panz VR, Raal FJ. From lipodystrophy syndromes to diabetes mellitus. Lancet. 2001 May 05; 357(9266):1379-81. PMID: 11356429.
      Citations: 15     Fields:    Translation:HumansAnimals
    225. Durst R, Colombo R, Shpitzen S, Avi LB, Friedlander Y, Wexler R, Raal FJ, Marais DA, Defesche JC, Mandelshtam MY, Kotze MJ, Leitersdorf E, Meiner V. Recent origin and spread of a common Lithuanian mutation, G197del LDLR, causing familial hypercholesterolemia: positive selection is not always necessary to account for disease incidence among Ashkenazi Jews. Am J Hum Genet. 2001 May; 68(5):1172-88. PMID: 11309683; PMCID: PMC1226098.
      Citations: 14     Fields:    Translation:HumansCells
    226. Raal FJ, Pappu AS, Illingworth DR, Pilcher GJ, Marais AD, Firth JC, Kotze MJ, Heinonen TM, Black DM. Inhibition of cholesterol synthesis by atorvastatin in homozygous familial hypercholesterolaemia. Atherosclerosis. 2000 Jun; 150(2):421-8. PMID: 10856535.
      Citations: 15     Fields:    Translation:HumansCTClinical Trials
    227. Raal FJ, Pieterse A. A patient requiring 1,000 units of insulin per day! S Afr Med J. 2000 Apr; 90(4):357-8. PMID: 10957917.
      Citations:    Fields:    Translation:Humans
    228. Paiker JE, Raal FJ, Veller M, von Arb M, Chetty N, Naran NH. Cell adhesion molecules - can they be used to predict coronary artery disease in patients with familial hypercholesterolaemia? Clin Chim Acta. 2000 Mar; 293(1-2):105-13. PMID: 10699426.
      Citations: 1     Fields:    Translation:HumansCTClinical Trials
    229. Paiker JE, Raal FJ, von Arb M. Auto-antibodies against oxidized LDL as a marker of coronary artery disease in patients with familial hypercholesterolaemia. Ann Clin Biochem. 2000 Mar; 37 ( Pt 2):174-8. PMID: 10735360.
      Citations: 5     Fields:    Translation:Humans
    230. Panz VR, Raal FJ, Wall JR, Joffe BI. Circulating endothelium-related adhesion molecules in black South African patients with Graves' disease. Endocrine. 2000 Feb; 12(1):21-3. PMID: 10855686.
      Citations: 2     Fields:    Translation:Humans
    231. Kraft HG, Lingenhel A, Raal FJ, Hohenegger M, Utermann G. Lipoprotein(a) in homozygous familial hypercholesterolemia. Arterioscler Thromb Vasc Biol. 2000 Feb; 20(2):522-8. PMID: 10669652.
      Citations: 38     Fields:    Translation:Humans
    232. Raal FJ, Pilcher GJ, Veller MG, Kotze MJ, Joffe BI. Efficacy of vitamin E compared with either simvastatin or atorvastatin in preventing the progression of atherosclerosis in homozygous familial hypercholesterolemia. Am J Cardiol. 1999 Dec 01; 84(11):1344-6, A7. PMID: 10614803.
      Citations: 3     Fields:    Translation:Humans
    233. Raal FJ, Panz VR, Pilcher GJ, Joffe BI. Atherosclerosis seems not to be associated with hyperinsulinaemia in patients with familial hypercholesterolaemia. J Intern Med. 1999 Jul; 246(1):75-80. PMID: 10447228.
      Citations: 1     Fields:    Translation:Humans
    234. Raal FJ, Pilcher GJ, Waisberg R, Buthelezi EP, Veller MG, Joffe BI. Low-density lipoprotein cholesterol bulk is the pivotal determinant of atherosclerosis in familial hypercholesterolemia. Am J Cardiol. 1999 May 01; 83(9):1330-3. PMID: 10235090.
      Citations: 7     Fields:    Translation:Humans
    235. Kotze MJ, Peeters AV, Loubser O, Theart L, du Plessis L, Hayes VM, de Jong G, de Villiers JN, Lombard CJ, Hansen PS, Raal FJ. Familial hypercholesterolemia: potential diagnostic value of mutation screening in a pediatric population of South Africa. Clin Genet. 1998 Jul; 54(1):74-8. PMID: 9727745.
      Citations: 1     Fields:    Translation:Humans
    236. Callis M, Jansen S, Thiart R, de Villiers JN, Raal FJ, Kotze MJ. Mutation analysis in familial hypercholesterolemia patients of different ancestries: identification of three novel LDLR gene mutations. Mol Cell Probes. 1998 Jun; 12(3):149-52. PMID: 9664576.
      Citations: 2     Fields:    Translation:HumansCells
    237. Thiart R, Loubser O, de Villiers JN, Marx MP, Zaire R, Raal FJ, Kotze MJ. Two novel and two known low-density lipoprotein receptor gene mutations in German patients with familial hypercholesterolemia. Hum Mutat. 1998; Suppl 1:S232-3. PMID: 9452095.
      Citations:    Fields:    Translation:Humans
    238. Raal FJ, Pilcher GJ, Illingworth DR, Pappu AS, Stein EA, Laskarzewski P, Mitchel YB, Melino MR. Expanded-dose simvastatin is effective in homozygous familial hypercholesterolaemia. Atherosclerosis. 1997 Dec; 135(2):249-56. PMID: 9430375.
      Citations: 17     Fields:    Translation:HumansCTClinical Trials
    239. Panz VR, Raal FJ, O'Rahilly S, Kedda MA, Joffe BI. Insulin receptor substrate-1 gene variants in lipoatrophic diabetes mellitus and non-insulin-dependent diabetes mellitus: a study of South African black and white subjects. Hum Genet. 1997 Nov; 101(1):118-9. PMID: 9385382.
      Citations: 4     Fields:    Translation:HumansCells
    240. Kotze MJ, de Villiers JN, Loubser O, Thiart R, Scholtz CL, Raal FJ. A double mutant LDL receptor allele in a cypriot family with heterozygous familial hypercholesterolemia. Hum Genet. 1997 Jul; 100(1):101-3. PMID: 9225977.
      Citations: 3     Fields:    Translation:Humans
    241. Kotze MJ, Loubser O, Thiart R, de Villiers JN, Langenhoven E, Theart L, Steyn K, Marais AD, Raal FJ. CpG hotspot mutations at the LDL receptor locus are a frequent cause of familial hypercholesterolaemia among South African Indians. Clin Genet. 1997 Jun; 51(6):394-8. PMID: 9237502.
      Citations: 6     Fields:    Translation:Humans
    242. Zouvanis M, Wing J, Raal FJ. Diagnosis of Cushing's syndrome. S Afr Med J. 1997 Mar; 87(3 Suppl):386. PMID: 9137362.
      Citations:    Fields:    
    243. Panz VR, Wing JR, Raal FJ, Kedda MA, Joffe BI. Improved glucose tolerance after effective lipid-lowering therapy with bezafibrate in a patient with lipoatrophic diabetes mellitus: a putative role for Randle's cycle in its pathogenesis? Clin Endocrinol (Oxf). 1997 Mar; 46(3):365-8. PMID: 9156048.
      Citations: 5     Fields:    Translation:Humans
    244. Raal FJ, Pilcher G, Rubinsztein DC, Lingenhel A, Utermann G. Statin therapy in a kindred with both apolipoprotein B and low density lipoprotein receptor gene defects. Atherosclerosis. 1997 Feb 28; 129(1):97-102. PMID: 9069523.
      Citations: 3     Fields:    Translation:HumansAnimals
    245. Chetty N, Naran NH, Walker AR, Seftel HC, Joffe BI, Raal FJ. Plasma fatty acid levels in South African interethnic male high school pupils at different ultimate risks of coronary heart disease. Clin Chim Acta. 1997 Feb 03; 258(1):31-46. PMID: 9049441.
      Citations:    Fields:    Translation:Humans
    246. Schnitzler CM, Wing JR, Raal FJ, van der Merwe MT, Mesquita JM, Gear KA, Robson HJ, Shires R. Fewer bone histomorphometric abnormalities with intermittent than with continuous slow-release sodium fluoride therapy. Osteoporos Int. 1997; 7(4):376-89. PMID: 9373574.
      Citations:    Fields:    Translation:Humans
    247. Raal FJ, Taylor DR, Joffe BI, Seftel HC. Comprehensive management of non-insulin-dependent diabetes mellitus. A diabetes clinic revisited. S Afr Med J. 1996 Aug; 86(8 Suppl):1007-8, 1013. PMID: 9180771.
      Citations: 1     Fields:    Translation:Humans
    248. Joannou J, Kalk WJ, Mahomed I, Ntsepo S, Berzin M, Joffe BI, Raal FJ, Sachs E, van der Merwe MT, Wing JR. Screening for diabetic retinopathy in South Africa with 60 degrees retinal colour photography. J Intern Med. 1996 Jan; 239(1):43-7. PMID: 8551199.
      Citations: 9     Fields:    Translation:HumansPHPublic HealthCTClinical Trials
    249. Raal FJ, Areias AJ, Waisberg R, von Arb M. Susceptibility of low density lipoprotein to oxidation in familial hypercholesterolaemia. Atherosclerosis. 1995 May; 115(1):9-15. PMID: 7669091.
      Citations:    Fields:    Translation:HumansCells
    250. Raal FJ, Areias AJ, Joffe BI. Low density lipoproteins and atherosclerosis-quantity or quality? Redox Rep. 1995 May; 1(3):171-6. PMID: 27414271.
      Citations:    Fields:    
    251. Zouvanis M, Raal FJ, Joffe BI, Seftel HC. Microalbuminuria is not associated with cardiovascular disease in patients with homozygous familial hypercholesterolaemia. Atherosclerosis. 1995 Mar; 113(2):289-92. PMID: 7605367.
      Citations:    Fields:    Translation:Humans
    252. Joffe BI, Segal I, Panz VR, Wing JR, Raal FJ, Seftel HC. Insulin resistance or insulin deficiency as precursor of non-insulin-dependent diabetes mellitus. Lancet. 1994 Dec 17; 344(8938):1705. PMID: 7996982.
      Citations:    Fields:    Translation:Humans
    253. Raal FJ, Kalk WJ, Lawson M, Esser JD, Buys R, Fourie L, Panz VR. Effect of moderate dietary protein restriction on the progression of overt diabetic nephropathy: a 6-mo prospective study. Am J Clin Nutr. 1994 Oct; 60(4):579-85. PMID: 8092094.
      Citations: 18     Fields:    Translation:HumansCTClinical Trials
    254. Raal FJ, Areias AJ, Pilcher GJ, Joffe BI, Seftel HC. Lack of effect of high dose vitamin E on xanthoma regression in homozygous familial hypercholesterolaemia. Atherosclerosis. 1994 Jun; 107(2):213-9. PMID: 7980695.
      Citations: 1     Fields:    Translation:HumansCells
    255. Seftel HC, Asvat MS, Joffe BI, Raal FJ, Panz VR, Vermaak WJ, Loock ME, Rajput MC, Omar MA, Jeenah MS, et al. Selected risk factors for coronary heart disease in male scholars from the major South African population groups. S Afr Med J. 1993 Dec; 83(12):891-7. PMID: 8115914.
      Citations: 4     Fields:    Translation:Humans
    256. Rubinsztein DC, Raal FJ, Seftel HC, Pilcher G, Coetzee GA, van der Westhuyzen DR. Characterization of six patients who are double heterozygotes for familial hypercholesterolemia and familial defective apo B-100. Arterioscler Thromb. 1993 Jul; 13(7):1076-81. PMID: 8318509.
      Citations: 6     Fields:    Translation:Humans
    257. Kalk WJ, Huddle KR, Raal FJ. The age of onset and sex distribution of insulin-dependent diabetes mellitus in Africans in South Africa. Postgrad Med J. 1993 Jul; 69(813):552-6. PMID: 8415343; PMCID: PMC2399890.
      Citations: 11     Fields:    Translation:Humans
    258. Joffe BI, Panz VR, Wing JR, Raal FJ, Seftel HC. Pathogenesis of non-insulin-dependent diabetes mellitus in the black population of southern Africa. Lancet. 1992 Aug 22; 340(8817):460-2. PMID: 1354791.
      Citations: 15     Fields:    Translation:Humans
    259. Raal FJ, Kalk WJ, Taylor DR, Osler CE, Panz VR. The relationship between the development and progression of microalbuminuria and arterial blood pressure in type 1 (insulin-dependent) diabetes mellitus. Diabetes Res Clin Pract. 1992 Jun; 16(3):221-7. PMID: 1425143.
      Citations:    Fields:    Translation:Humans
    260. Kalk WJ, Kruger M, Slabbert A, Osler C, Raal FJ. Fat, protein and carbohydrate content of diets of white insulin-dependent diabetic adolescents and young adults. S Afr Med J. 1992 Apr 18; 81(8):399-402. PMID: 1566210.
      Citations: 1     Fields:    Translation:Humans
    261. Joffe BI, Panz VR, Wing JR, Raal FJ, Seftel HC. Relationship between plasma insulin and blood pressure in South African black women in Johannesburg. Diabetes Care. 1992 Apr; 15(4):556-8. PMID: 1499478.
      Citations:    Fields:    Translation:Humans
    262. Panz VR, Joffe BI, Wing JR, Raal FJ, Seftel HC. Insulin-receptor activity in nondiabetic and diabetic urbanized South African black women. Diabetes Care. 1992 Feb; 15(2):277-81. PMID: 1547686.
      Citations:    Fields:    Translation:HumansCells
    263. Heney C, Song E, Kellen A, Raal F, Miller SD, Davis V. Cerebral phaeohyphomycosis caused by Xylohypha bantiana. Eur J Clin Microbiol Infect Dis. 1989 Nov; 8(11):984-8. PMID: 2513200.
      Citations: 8     Fields:    Translation:HumansAnimals
    264. Raal FJ, Wypkema EM, Baynes RD. Haematological abnormalities in the acquired immunodeficiency syndrome. S Afr Med J. 1988 Aug 20; 74(4):157-60. PMID: 3261456.
      Citations: 2     Fields:    Translation:HumansCells
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