"Interleukin-18" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cytokine which resembles IL-1 structurally and IL-12 functionally. It enhances the cytotoxic activity of NK CELLS and CYTOTOXIC T-LYMPHOCYTES, and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity.
| Descriptor ID |
D020382
|
| MeSH Number(s) |
D12.644.276.374.465.518 D12.776.467.374.465.518 D23.529.374.465.518
|
| Concept/Terms |
Interleukin-18- Interleukin-18
- Interleukin 18
- IFN-gamma-Inducing Factor
- IL-18
- Interferon-gamma Inducing Factor
- Inducing Factor, Interferon-gamma
- Interferon gamma Inducing Factor
- Interferon-gamma-Inducing Factor
- IFN-gamma Inducing Factor
- IFN gamma Inducing Factor
- Inducing Factor, IFN-gamma
- IL18
|
Below are MeSH descriptors whose meaning is more general than "Interleukin-18".
Below are MeSH descriptors whose meaning is more specific than "Interleukin-18".
This graph shows the total number of publications written about "Interleukin-18" by people in this website by year, and whether "Interleukin-18" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 2 | 3 |
| 1999 | 1 | 0 | 1 |
| 2000 | 1 | 0 | 1 |
| 2006 | 0 | 1 | 1 |
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Below are the most recent publications written about "Interleukin-18" by people in Profiles.
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The effect of abdominal obesity on insulin sensitivity and serum lipid and cytokine concentrations in African women. Clin Endocrinol (Oxf). 2006 May; 64(5):535-41.
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A short course of oral aspirin increases IL-18-induced interferon-gamma production in whole blood cultures. Eur Cytokine Netw. 2000 Sep; 11(3):379-82.
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Gene expression, synthesis, and secretion of interleukin 18 and interleukin 1beta are differentially regulated in human blood mononuclear cells and mouse spleen cells. Proc Natl Acad Sci U S A. 1999 Mar 02; 96(5):2256-61.
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Interleukin-18 enhances lipopolysaccharide-induced interferon-gamma production in human whole blood cultures. J Infect Dis. 1998 Dec; 178(6):1830-4.
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Interleukin-18 regulation of interferon gamma production and cell proliferation as shown in interleukin-1beta-converting enzyme (caspase-1)-deficient mice. Blood. 1998 Mar 15; 91(6):2118-25.
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Interleukin-18 (IFNgamma-inducing factor) induces IL-8 and IL-1beta via TNFalpha production from non-CD14+ human blood mononuclear cells. J Clin Invest. 1998 Feb 01; 101(3):711-21.