HIV Reverse Transcriptase
"HIV Reverse Transcriptase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A reverse transcriptase encoded by the POL GENE of HIV. It is a heterodimer of 66 kDa and 51 kDa subunits that are derived from a common precursor protein. The heterodimer also includes an RNAse H activity (RIBONUCLEASE H, HUMAN IMMUNODEFICIENCY VIRUS) that plays an essential role the viral replication process.
| Descriptor ID |
D054303
|
| MeSH Number(s) |
D08.811.913.696.445.308.300.750.187 D12.776.964.775.375.545.875 D12.776.964.775.375.750.187 D12.776.964.775.562.764.875 D12.776.964.970.600.850.375.545.875 D12.776.964.970.600.850.375.750.187
|
| Concept/Terms |
HIV Reverse Transcriptase- HIV Reverse Transcriptase
- Transcriptase, HIV Reverse
- Reverse Transcriptase, Human Immunodeficiency Virus
- Reverse Transcriptase, HIV
|
Below are MeSH descriptors whose meaning is more general than "HIV Reverse Transcriptase".
Below are MeSH descriptors whose meaning is more specific than "HIV Reverse Transcriptase".
This graph shows the total number of publications written about "HIV Reverse Transcriptase" by people in this website by year, and whether "HIV Reverse Transcriptase" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 1 | 0 | 1 |
| 2005 | 2 | 1 | 3 |
| 2006 | 0 | 2 | 2 |
| 2008 | 0 | 2 | 2 |
| 2009 | 1 | 2 | 3 |
| 2010 | 1 | 0 | 1 |
| 2011 | 1 | 1 | 2 |
| 2012 | 2 | 2 | 4 |
| 2013 | 1 | 0 | 1 |
| 2014 | 2 | 0 | 2 |
| 2015 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
| 2024 | 1 | 1 | 2 |
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Below are the most recent publications written about "HIV Reverse Transcriptase" by people in Profiles.
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Thymidine Analogue Mutations with M184V Significantly Decrease Phenotypic Susceptibility of HIV-1 Subtype C Reverse Transcriptase to Islatravir. Viruses. 2024 12 06; 16(12).
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Performance of an in-house multiplex PCR assay for HIV-1 drug resistance testing - A cheaper alternative. J Virol Methods. 2024 Dec; 330:115034.
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Reduced efficacy of HIV-1 integrase inhibitors in patients with drug resistance mutations in reverse transcriptase. Nat Commun. 2020 12 01; 11(1):5922.
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Mutational Correlates of Virological Failure in Individuals Receiving a WHO-Recommended Tenofovir-Containing First-Line Regimen: An International Collaboration. EBioMedicine. 2017 Apr; 18:225-235.
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Geographic and temporal trends in the molecular epidemiology and genetic mechanisms of transmitted HIV-1 drug resistance: an individual-patient- and sequence-level meta-analysis. PLoS Med. 2015 Apr; 12(4):e1001810.
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Novel indole based NNRTIs with improved potency against wild type and resistant HIV. Bioorg Med Chem Lett. 2014 Sep 15; 24(18):4376-4380.
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Concordance between allele-specific PCR and ultra-deep pyrosequencing for the detection of HIV-1 non-nucleoside reverse transcriptase inhibitor resistance mutations. J Virol Methods. 2014 Oct; 207:182-7.
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A pragmatic approach to HIV-1 drug resistance determination in resource-limited settings by use of a novel genotyping assay targeting the reverse transcriptase-encoding region only. J Clin Microbiol. 2013 Jun; 51(6):1757-61.
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Frequent emergence of N348I in HIV-1 subtype C reverse transcriptase with failure of initial therapy reduces susceptibility to reverse-transcriptase inhibitors. Clin Infect Dis. 2012 Sep; 55(5):737-45.
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HIV-1 phenotypic reverse transcriptase inhibitor drug resistance test interpretation is not dependent on the subtype of the virus backbone. PLoS One. 2012; 7(4):e34708.