"Clarithromycin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A semisynthetic macrolide antibiotic derived from ERYTHROMYCIN that is active against a variety of microorganisms. It can inhibit PROTEIN SYNTHESIS in BACTERIA by reversibly binding to the 50S ribosomal subunits. This inhibits the translocation of aminoacyl transfer-RNA and prevents peptide chain elongation.
| Descriptor ID |
D017291
|
| MeSH Number(s) |
D02.540.576.500.992.100
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Clarithromycin".
Below are MeSH descriptors whose meaning is more specific than "Clarithromycin".
This graph shows the total number of publications written about "Clarithromycin" by people in this website by year, and whether "Clarithromycin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1997 | 1 | 0 | 1 |
| 2000 | 0 | 1 | 1 |
| 2007 | 2 | 0 | 2 |
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Below are the most recent publications written about "Clarithromycin" by people in Profiles.
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Clinical and bacteriological outcomes in hospitalised patients with community-acquired pneumonia treated with azithromycin plus ceftriaxone, or ceftriaxone plus clarithromycin or erythromycin: a prospective, randomised, multicentre study. Clin Microbiol Infect. 2007 Feb; 13(2):162-171.
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Clarithromycin alone and in combination with ceftriaxone inhibits the production of pneumolysin by both macrolide-susceptible and macrolide-resistant strains of Streptococcus pneumoniae. J Antimicrob Chemother. 2007 Feb; 59(2):224-9.
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Investigation of the anti-inflammatory and membrane-stabilizing potential of spiramycin in vitro. J Antimicrob Chemother. 2000 Aug; 46(2):269-71.
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Roxithromycin, clarithromycin, and azithromycin attenuate the injurious effects of bioactive phospholipids on human respiratory epithelium in vitro. Inflammation. 1997 Dec; 21(6):655-65.
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Membrane-stabilizing, anti-inflammatory interactions of macrolides with human neutrophils. Inflammation. 1996 Dec; 20(6):693-705.