Antibody-Dependent Cell Cytotoxicity
"Antibody-Dependent Cell Cytotoxicity" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The phenomenon of antibody-mediated target cell destruction by non-sensitized effector cells. The identity of the target cell varies, but it must possess surface IMMUNOGLOBULIN G whose Fc portion is intact. The effector cell is a "killer" cell possessing Fc receptors. It may be a lymphocyte lacking conventional B- or T-cell markers, or a monocyte, macrophage, or polynuclear leukocyte, depending on the identity of the target cell. The reaction is complement-independent.
| Descriptor ID |
D000920
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| MeSH Number(s) |
G12.287.070
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| Concept/Terms |
Antibody-Dependent Cell Cytotoxicity- Antibody-Dependent Cell Cytotoxicity
- Antibody Dependent Cell Cytotoxicity
- Cell Cytoxicity, Antibody-Dependent
- Antibody-Dependent Cell Cytoxicities
- Antibody-Dependent Cell Cytoxicity
- Cell Cytoxicities, Antibody-Dependent
- Cell Cytoxicity, Antibody Dependent
- Cytoxicities, Antibody-Dependent Cell
- Cytoxicity, Antibody-Dependent Cell
- ADCC
- Cytotoxicity, Antibody-Dependent Cell
- Antibody-Dependent Cell Cytotoxicities
- Cell Cytotoxicities, Antibody-Dependent
- Cell Cytotoxicity, Antibody-Dependent
- Cytotoxicities, Antibody-Dependent Cell
- Cytotoxicity, Antibody Dependent Cell
|
Below are MeSH descriptors whose meaning is more general than "Antibody-Dependent Cell Cytotoxicity".
Below are MeSH descriptors whose meaning is more specific than "Antibody-Dependent Cell Cytotoxicity".
This graph shows the total number of publications written about "Antibody-Dependent Cell Cytotoxicity" by people in this website by year, and whether "Antibody-Dependent Cell Cytotoxicity" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2016 | 0 | 1 | 1 |
| 2018 | 3 | 0 | 3 |
| 2019 | 2 | 2 | 4 |
| 2021 | 2 | 2 | 4 |
| 2022 | 1 | 1 | 2 |
| 2023 | 1 | 0 | 1 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Antibody-Dependent Cell Cytotoxicity" by people in Profiles.
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SARS-CoV-2 BA.4/5 infection triggers more cross-reactive Fc?RIIIa signaling and neutralization than BA.1, in the context of hybrid immunity. J Virol. 2024 Jul 23; 98(7):e0067824.
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Despite delayed kinetics, people living with HIV achieve equivalent antibody function after SARS-CoV-2 infection or vaccination. Front Immunol. 2023; 14:1231276.
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Antibody-dependent cellular cytotoxicity against SARS-CoV-2 Omicron sub-lineages is reduced in convalescent sera regardless of infecting variant. Cell Rep Med. 2023 01 17; 4(1):100910.
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Enhanced neutralization potency of an identical HIV neutralizing antibody expressed as different isotypes is achieved through genetically distinct mechanisms. Sci Rep. 2022 10 01; 12(1):16473.
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ADCC-mediating non-neutralizing antibodies can exert immune pressure in early HIV-1 infection. PLoS Pathog. 2021 11; 17(11):e1010046.
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Selection of HIV Envelope Strains for Standardized Assessments of Vaccine-Elicited Antibody-Dependent Cellular Cytotoxicity-Mediating Antibodies. J Virol. 2022 01 26; 96(2):e0164321.
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HIV Broadly Neutralizing Antibodies Expressed as IgG3 Preserve Neutralization Potency and Show Improved Fc Effector Function. Front Immunol. 2021; 12:733958.
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Innate immune signatures to a partially-efficacious HIV vaccine predict correlates of HIV-1 infection risk. PLoS Pathog. 2021 03; 17(3):e1009363.
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Antibody-Dependent Cellular Cytotoxicity (ADCC)-Mediating Antibodies Constrain Neutralizing Antibody Escape Pathway. Front Immunol. 2019; 10:2875.
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Vaccine-Induced Antibodies Mediate Higher Antibody-Dependent Cellular Cytotoxicity After Interleukin-15 Pretreatment of Natural Killer Effector Cells. Front Immunol. 2019; 10:2741.