A highly conserved family of ATPases that facilitate the transport of lipids and cations across the plasma membrane. Structurally, they are elongated ALPHA-HELICES constituting five functionally distinct domains: three cytoplasmic domains A, N, and P which contain the catalytic sites, and two transmembrane domains. The N domain phosphorylates the P-domain at an invariant ASPARTATE residue, which, in turn, is dephosphorylated by the A domain. The phosphorylation and dephosphorylation cycles drive conformational changes in the protein between two states (E1 and E2), which allow the substrate to access the other side of the membrane.

Descriptor ID	D000073779
MeSH Number(s)	D08.811.277.040.025.314 D12.776.157.530.813 D12.776.543.585.813
Concept/Terms	P-type ATPases P-type ATPases ATPases, P-type P type ATPases Phosphorylation-type ATPases ATPases, Phosphorylation-type Phosphorylation type ATPases P-type Adenosine Triphosphatases Adenosine Triphosphatases, P-type P type Adenosine Triphosphatases Triphosphatases, P-type Adenosine Phosphorylation-type Adenosine Triphosphatases Adenosine Triphosphatases, Phosphorylation-type Phosphorylation type Adenosine Triphosphatases Triphosphatases, Phosphorylation-type Adenosine E1-E2 ATPases ATPases, E1-E2 E1 E2 ATPases

Below are MeSH descriptors whose meaning is more general than "P-type ATPases".

Below are MeSH descriptors whose meaning is related to "P-type ATPases".

Below are MeSH descriptors whose meaning is more specific than "P-type ATPases".